Table 2.

Incidence rate and trend in cardia gastric cancer among US adults aged ≥20, 2000–2019.

	Case Number No. %	Incidence rate, 2000 (95% CI)	Incidence rate, 2019 (95% CI)	Average APC, 2000-2009 (95% CI)	Average APC, 2010-2019 (95% CI)	Average APC, 2000–2019 (95% CI)
Overall	61,789	2.9 (2.8–3.0)	2.7 (2.6–2.8)	0.2 (−0.1 to 0.6)	−0.6 (−1.5 to 0.2)	−0.2 (−0.7 to 0.3)
Sex
Men	47,516 (76.9)	5.0 (4.8–5.2)	4.6 (4.4–4.8)	−0.6 (−1.3 to 0.1)	−0.6 (−1.8 to 0.1)	−0.6 (−1.3 to 0.1)
Women	14,273 (23.1)	1.2 (1.1–1.3)	1.2 (1.1–1.3)	0.2 (−0.1 to 0.5)	0.2 (−0.1 to 0.5)	0.2 (−0.1 to 0.5)
Age
20–64	24,683 (39.9)	1.3 (1.2–1.4)	1.2 (1.2–1.3)	−0.2 (−0.4 to 0.1)	−0.2 (−0.4 to 0.1)	−0.2 (−0.4 to 0.1)
≥65§	37,106 (60.1)	10.1 (9.6–10.6)	9.7 (9.3–10.1)	0.5* (0.0 to 0.9)	−0.9 (−1.8 to 0.0)	−0.2 (−0.7 to 0.3)
Race/ethnicity#
Non-Hispanic White	48,496 (78.5)	3.1 (3.0–3.3)	3.1 (3.0–3.3)	0.0 (−0.6 to 0.6)	−0.2 (−1.1 to 0.7)	0.0 (−0.6 to 0.7)
Non-Hispanic Black	3,753 (6.1)	1.9 (1.6–2.2)	1.7 (1.5–2.0)	−0.5 (−0.9 to 0.0)	−0.5 (−0.9 to 0.0)	−0.5 (−0.9 to 0.0)
Hispanic	6,113 (9.9)	2.3 (1.9–2.7)	2.1 (1.9–2.3)	−0.8* (−1.4 to −0.3)	−0.8* (−1.4 to −0.3)	−0.8* (−1.4 to −0.3)
Non-Hispanic API	3,044 (4.9)	2.4 (1.9–2.9)	2.1 (1.8–2.4)	−0.5 (−1.3 to 0.3)	−0.5 (−1.3 to 0.3)	−0.5 (−1.3 to 0.3)
Geographic location
Metropolitan	54,098 (87.6)	2.9 (2.8–3.0)	2.7 (2.6–2.8)	−0.5 (−1.2 to 0.2)	−0.7 (−1.6 to 0.3)	−0.5 (−1.2 to 0.2)
Nonmetropolitan	7,624 (12.3)	2.7 (2.4–3.0)	2.9 (2.6–3.2)	0.8* (0.4 to 1.3)	0.8* (0.4 to 1.3)	0.8* (0.4 to 1.3)

APC, annual percentage change; API, Asian and Pacific Islander.

^*Indicates the average APC was significantly different from zero.

^#The stratified analysis by race/ethnicity was limited among Non-Hispanic White, Non-Hispanic Black, Hispanic and Non-Hispanic API.

^§Indicates that the average APCs of 2000–2009 and 2010–2019 was significantly different.