Table 3.
Diagnostic accuracy criteria calculated by receiver-operating curve analysis for Vitamin D3 levels in Helicobacter pylori immunoglobulin G, immunoglobulin A, and immunoglobulin M serum-positive or -negative patients
| Serologic factor | n | HPY disease prevalence based on the antibody serum level (%) | Accuracy criteria for 25-OH-Vitamin D3 values | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||
| AUC (accuracy %)† | Cutoff (95% CI) | 95% CI | ||||||||
|
| ||||||||||
| P | Specificity% | Sensitivity% | PPV% | NPV% | ||||||
| IgG (AU/mL) | 455 | Positive | 271 (59.56) | 0.608 (66.23) | >32.80 (>32.51->39.06) | <0.001* | 30.43 (23.9-37.6) | 90.41 (86.3-93.6) | 65.7 (60.6-70.5) | 68.3 (57.1-78.1) |
| Negative | 184 (40.44) | |||||||||
| IgA (AU/mL) | 268 | Positive | 81 (30.22) | 0.644 (60.45) | >37.83 (>35.04->46.09) | <0.001* | 58.82 (51.4-66.0) | 64.20 (52.8-74.6) | 40.3 (31.8-49.3) | 79.1 (71.4-85.6) |
| Negative | 187 (69.78) | |||||||||
| IgM (U/mL) | 78 | Positive | 3 (3.85) | 0.720 (58.97) | >37.32 (>36.18->39.72) | 0.0168* | 57.33 (45.4-68.7) | 100.00 (29.2-100.0) | 8.6 (1.8-23.1) | 100.0 (91.8-100.0) |
| Negative | 75 (96.15) | |||||||||
*Significant result, †For accuracy estimations the online tool is used: https://www.omnicalculator.com/statistics/accuracy. IgA: Immunoglobulin A, IgG: Immunoglobulin G, IgM: Immunoglobulin M, n: sample size, CI: Confidence interval, AUC: Area under curve, PPV: Positive predictive value, NPV: Negative predictive value, HPY: Helicobacter pylori