TABLE 2.
IL-10 production in spleen cell cultures obtained from IFN-γ-deficient mice
| Infection status and time postinfectiona | IL-10 titer (ng/ml)b in:
|
|
|---|---|---|
| IFN-γ+/+ mice | IFN-γ−/− mice | |
| Uninfected | 4.5 ± 3.0 | 4.3 ± 2.5 |
| Infected | ||
| 7 days | 18.5 ± 6.8c | 16.7 ± 5.4c |
| 21 days | 21.0 ± 10.5c | 13.4 ± 5.0c |
a
Mice were infected with 107 CFU of S. aureus.
b
Spleen cells were stimulated with heat-killed S. aureus for 48 h, and the IL-10, titer in each culture supernatant was determined. Each result represents the mean ± standard deviation for a group of four mice. The results were reproduced in three repeated experiments.
c
Significantly different from the value for the uninfected group (P < 0.01).