Table 1.

Relative ECM composition.

ECM protein	Healthy		CDH+		p-value	CDH+ fold change w.r.t. Healthy
	Mean	±	Mean	±		Mean	±
Biglycan	1.15	0.27	0.97	0.32	0.50	0.84	0.28
Col1a1	10.30	1.34	10.01	0.15	0.73	0.97	0.01
Col1a2	3.86	0.63	4.09	0.16	0.57	1.06	0.04
Col2a1	0.98	0.66	0.32	0.02	0.16	0.33	0.02
Col3a1	2.58	0.67	2.13	0.53	0.42	0.83	0.21
Col4a1	1.75	0.06	2.15	0.13	0.01	1.23	0.07
Col4a2	0.60	0.27	0.66	0.34	0.84	1.09	0.57
Col5a2	0.42	0.38	0.75	0.14	0.23	1.76	0.33
Col6a1	2.53	0.93	2.38	0.59	0.83	0.94	0.23
Col6a2	1.32	0.40	2.39	0.63	0.07	1.81	0.47
Col6a3	1.78	0.41	1.93	0.57	0.73	1.08	0.32
Col6a6	0.15	0.26	0.63	0.29	0.09	4.27	1.92
Col12a1	0.68	0.88	0.86	0.19	0.74	1.27	0.28
Col14a1	2.11	0.63	0.98	0.38	0.06	0.47	0.18
Col18a1	0.00	0.00	0.32	0.33	0.17	Inf	Inf
Elastin	0.54	0.54	0.64	0.29	0.80	1.18	0.54
EMILIN-1	1.91	0.49	2.29	0.67	0.47	1.20	0.35
EMILIN-2	0.60	1.03	0.21	0.18	0.56	0.35	0.31
Fibrillin-1	18.68	1.74	20.25	2.06	0.37	1.08	0.11
Fibrillin-2	13.38	3.47	14.45	0.71	0.63	1.08	0.05
Fibronectin	8.83	2.39	8.71	0.19	0.94	0.99	0.02
Fibulin-2	0.24	0.41	0.54	0.38	0.40	2.28	1.61
Fibulin-5	1.39	1.27	0.77	0.40	0.46	0.55	0.29
Laminin alpha-2	0.19	0.32	0.11	0.20	0.76	0.61	1.05
Laminin alpha-4	0.37	0.65	0.00	0.00	0.37	0.00	0.00
Laminin alpha-5	1.14	0.62	0.75	0.50	0.45	0.66	0.44
Laminin beta-1	1.62	1.07	0.85	0.47	0.32	0.53	0.29
Laminin beta-2	1.07	0.94	1.28	0.25	0.73	1.20	0.23
Laminin gamma-1	1.81	0.99	2.03	0.64	0.76	1.13	0.35
Nidogen-1	1.49	1.36	1.17	0.76	0.74	0.79	0.51
Nidogen-2	0.68	0.67	0.32	0.33	0.44	0.47	0.48
Periostin	3.63	1.25	3.32	0.52	0.71	0.91	0.14
Perlecan	11.86	1.35	11.26	1.22	0.60	0.95	0.10
Versican	0.36	0.62	0.45	0.39	0.84	1.25	1.08

Determined from spectral counts, data are percentages of total ECM spectra. Last column is fold change of CDH+ ECM components with respect to Healthy. Those in red show down regulation below 0.5-fold while those in green show upregulation greater than 1.5-fold.