Table 2. The 19 high-risk missense variants of the CYP1B1 gene that were predicted to be “damaging” or “deleterious” by all the seven pieces of software.
| rs IDs | Variant | SIFT | PolyPhen 2 | PROVEAN | PANTHER | SNAP2 | Phd SNP | Predict SNP | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Score | Prediction | Score | Prediction | Score | Prediction | Score | Prediction | Score | Prediction | Prediction | Score | Prediction | ||
| rs201824781 | P52L | 0 | Deleterious | 1 | Probably Damaging | −6.33 | Deleterious | 0.85 | Probably Damaging | 58 | effect | Disease | 0.86908 | Deleterious |
| rs28936700 | G61E | 0 | Deleterious | 1 | Probably Damaging | −6.60 | Deleterious | 0.85 | Probably Damaging | 90 | effect | Disease | 0.86908 | Deleterious |
| rs112014184 | G90R | 0 | Deleterious | 1 | Probably Damaging | −6.94 | Deleterious | 0.85 | Probably Damaging | 91 | effect | Disease | 0.86908 | Deleterious |
| rs73625096 | P118L | 0 | Deleterious | 1 | Probably Damaging | −8.41 | Deleterious | 0.85 | Probably Damaging | 73 | effect | Disease | 0.86908 | Deleterious |
| rs72481807 | E173K | 0 | Deleterious | 1 | Probably Damaging | −3.25 | Deleterious | 0.78 | Probably Damaging | 84 | effect | Disease | 0.86908 | Deleterious |
| rs72480439 | D291G | 0.015 | Deleterious | 0.985 | Probably Damaging | −6.30 | Deleterious | 0.85 | Probably Damaging | 84 | effect | Disease | 0.86908 | Deleterious |
| rs200182794 | Y349D | 0.022 | Deleterious | 0.917 | Probably Damaging | −6.45 | Deleterious | 0.74 | Probably Damaging | 38 | effect | Disease | 0.86908 | Deleterious |
| rs55771538 | G365R | 0.003 | Deleterious | 0.991 | Probably Damaging | −6.24 | Deleterious | 0.85 | Probably Damaging | 72 | effect | Disease | 0.86908 | Deleterious |
| rs55771538 | G365W | 0 | Deleterious | 0.998 | Probably Damaging | −6.34 | Deleterious | 0.85 | Probably Damaging | 75 | effect | Disease | 0.86908 | Deleterious |
| rs72480442 | R368C | 0 | Deleterious | 0.996 | Probably Damaging | −7.34 | Deleterious | 0.85 | Probably Damaging | 92 | effect | Disease | 0.60548 | Deleterious |
| rs79204362 | R368H | 0.01 | Deleterious | 0.978 | Probably Damaging | −4.59 | Deleterious | 0.85 | Probably Damaging | 90 | effect | Disease | 0.86908 | Deleterious |
| rs104893622 | D374N | 0.006 | Deleterious | 0.981 | Probably Damaging | −4.74 | Deleterious | 0.85 | Probably Damaging | 59 | effect | Disease | 0.71871 | Deleterious |
| rs104893629 | N423Y | 0.001 | Deleterious | 1 | Probably Damaging | −7.62 | Deleterious | 0.85 | Probably Damaging | 89 | effect | Disease | 0.86908 | Deleterious |
| rs201181935 | D430E | 0.002 | Deleterious | 0.922 | Probably Damaging | −3.57 | Deleterious | 0.85 | Probably Damaging | 59 | effect | Disease | 0.86908 | Deleterious |
| rs72481808 | P442A | 0.022 | Deleterious | 1 | Probably Damaging | −7.53 | Deleterious | 0.85 | Probably Damaging | 34 | effect | Disease | 0.86908 | Deleterious |
| rs72549376 | R444Q | 0.003 | Deleterious | 1 | Probably Damaging | −3.77 | Deleterious | 0.85 | Probably Damaging | 69 | effect | Disease | 0.86908 | Deleterious |
| rs148233007 | F445L | 0 | Deleterious | 1 | Probably Damaging | −5.66 | Deleterious | 0.85 | Probably Damaging | 93 | effect | Disease | 0.86908 | Deleterious |
| rs28936701 | R469W | 0 | Deleterious | 1 | Probably Damaging | −7.28 | Deleterious | 0.74 | Probably Damaging | 98 | effect | Disease | 0.60697 | Deleterious |
| rs104894979 | C470Y | 0 | Deleterious | 1 | Probably Damaging | −10.10 | Deleterious | 0.85 | Probably Damaging | 89 | effect | Disease | 0.86908 | Deleterious |