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. 2022 Sep 1;23(1):312–325. doi: 10.1111/1755-0998.13704

FIGURE 2.

FIGURE 2

SMD algorithm for defining modules. SMD defines a module as a group where all features have a correlation above a given threshold. To do this SMD first uses complete linkage hierarchical clustering on correlation coefficients to create a tree. Each module is defined as a subtree where the correlation coefficients between all tips are greater than the threshold.