Table 2.
The pooled sensitivity, specificity, diagnostic odds ratio, area under the curve, positive likelihood ratio, and negative likelihood ratio of AFP and AFP combined with other biomarkers.
| Markers | Sensitivity (95% CI) | Specificity (95% CI) | PLR (95% CI) | NLR (95% CI) | DOR (95% CI) | AUC |
|---|---|---|---|---|---|---|
| AFP | 0.61 [0.57, 0.65] | 0.87 [0.83, 0.90] | 4.50 [3.60, 5.80] | 0.45 [0.41, 0.49] | 10.00 [8.00, 13.00] | 0.78 |
| AFP + AFP-L3 | 0.56 [0.45, 0.66] | 0.90 [0.88, 0.92] | 5.80 [4.70, 7.31] | 0.49 [0.39, 0.61] | 12.00 [8.00, 18.00] | 0.90 |
| AFP + AFP-L3 + DCP | 0.62 [0.49, 0.74] | 0.93 [0.84, 0.97] | 9.00 [4.50, 17.90] | 0.40 [0.30, 0.54] | 22.00 [13.00, 38.00] | 0.85 |
| AFP + DCP | 0.81 [0.73, 0.88] | 0.86 [0.75, 0.93] | 6.00 [3.40, 10.60] | 0.21 [0.15, 0.30] | 28.00 [17.00, 47.00] | 0.90 |
| AFP/DCP | 0.80 [0.68, 0.88] | 0.85 [0.74, 0.92] | 5.30 [3.20, 8.90] | 0.24 [0.16, 0.36] | 22.00 [13.00, 38.00] | 0.89 |
| AFP + GPC3 | 0.86 [0.80, 0.90] | 0.89 [0.79, 0.95] | 8.10 [3.80, 17.20] | 0.16 [0.12, 0.22] | 50.00 [20.00, 127.00] | 0.91 |
PLR: positive likelihood ratio; NLR: negative likelihood ratio; DOR: diagnostic odds ratio; CI: confidence interval; AUC: area under the curve.