Table 4.

The pooled sensitivity, specificity, diagnostic odds ratio, area under the curve, positive likelihood ratio, and negative likelihood ratio of other biomarkers.

Markers	Sensitivity (95% CI)	Specificity (95% CI)	PLR (95% CI)	NLR (95% CI)	DOR (95% CI)	AUC
DCP	0.71 [0.64, 0.77]	0.91 [0.87, 0.93]	7.8 [5.70, 10.50]	0.32 [0.26, 0.40]	24.00 [16.00, 36.00]	0.90
GPC3	0.71 [0.63, 0.77]	0.87 [0.77, 0.93]	5.50 [2.90, 10.40]	0.33 [0.26, 0.43]	17.00 [7.00, 37.00]	0.82
GP73	0.88 [0.65, 0.96]	0.90 [0.68, 0.98]	8.90 [2.30, 33.90]	0.14 [0.04, 0.45]	66.00 [9.00, 502.00]	0.95
DKK1	0.70 [0.44, 0.87]	0.77 [0.62, 0.87]	3.10 [2.00, 4.80]	0.39 [0.20, 0.77]	8.00 [3.00, 18.00]	0.81
AFP-L3	0.56 [0.42, 0.70]	0.89 [0.83, 0.94]	5.40 [3.70, 7.70]	0.49 [0.36, 0.66]	11.00 [7.00, 18.00]	0.85
AFU	0.71 [0.66, 0.75]	0.59 [0.51, 0.66]	1.70 [1.40, 2.10]	0.50 [0.40, 0.63]	3.00 [2.00, 5.00]	0.71
CA199	0.50 [0.27, 0.72]	0.83 [0.71, 0.90]	2.90 [2.40, 3.50]	0.61 [0.42, 0.88]	5.00 [3.00, 7.00]	0.78
Hsp90alpha	0.87 [0.69, 0.95]	0.89 [0.84, 0.93]	8.20 [5.60, 11.90]	0.15 [0.06, 0.37]	55.00 [24.00, 126.00]	0.94
Midkine	0.93 [0.76, 0.98]	0.85 [0.73, 0.93]	6.40 [3.10, 13.30]	0.08 [0.02, 0.33]	78.00 [11.00, 582.00]	0.94
OPN	0.85 [0.70, 0.93]	0.85 [0.74, 0.92]	5.60 [2.80, 11.40]	0.18 [0.08, 0.41]	31.00 [7.00, 137.00]	0.91

PLR: positive likelihood ratio; NLR: negative likelihood ratio; DOR: diagnostic odds ratio; CI: confidence interval; AUC: area under the curve.