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. Author manuscript; available in PMC: 2022 Dec 12.
Published in final edited form as: Cell Rep. 2022 Nov 1;41(5):111576. doi: 10.1016/j.celrep.2022.111576

Figure 7. Unaltered enhancer-promoter contacts after NUP93 acute depletion and a model figure.

Figure 7.

(A and B) Aggregate peak analyses (APAs) of HiChIP loops formed between NDE enhancers and NDG promoters using H3K27ac or H3K4me1 HiChIP data under control and 8-h IAA conditions (5-kb resolution). The top left corner values represent APA scores calculated with respect to the enrichment of the center pixel and neighborhood.

(C and D) HiChIP contact maps from an example region, showing overall unaltered chromatin loops under control and IAA (acute NUP93 depletion) conditions (5-kb resolution).

(E) A model summarizing the results of this study, which revealed the direct roles and nuclear locations of core NUPs, particularly NUP93, in transcription control in human cells. NDE, NUP93-dependent enhancer; NDG, NUP93-dependent gene.