Table 1. Model parameter values.
Parameters with no units are dimensionless. All estimates were obtained by fitting the model to in vitro data, except those marked with a * which are assumed.
| Name (unit) | Symbol | Estimate | Range for sensitivity analysis | Reference | |
|---|---|---|---|---|---|
| Bacterial growth parameters | Carrying capacity (bacteria.mL-1) | Nmax | 2.76 x 109 | - | [28] |
| BE growth rate (h-1) | μmaxE | 1.61 | 1.59–1.63 | ||
| BT growth rate (h-1) | μmaxT | 1.51 | 1.49–1.53 | ||
| BET growth rate (h-1) | μmaxET | 1.44 | 1.42–1.47 | ||
| Phage parameters | Phage adsorption rate (phage-1.h-1) | β | 2.3 x 10−10 | 2.1 x 10−10–2.7 x 10−10 | |
| Phage concentration at half saturation (phage.mL-1) | P50 | 1.19 x 1010 | 1.02 x 1010–1.29 x 1010 | ||
| Phage burst size (phage) | δmax | 50 | 43–54 | ||
| Phage latent period (h) | τ | 0.61 | 0.60–0.77 | ||
| Transduction probability (phage-1) | α | 1.19 x 10−8 | 1.11 x 10−8–1.31 x 10−8 | ||
| Phage decay rate (h-1) | γP | 0* | 0–0.1 | [50] | |
| Antibiotic parameters | Erythromycin decay rate (h-1) | γE | 0* | 0–0.1 | [51] |
| Tetracycline decay rate (h-1) | γT | 0* | 0–0.1 | ||
| Erythromycin-induced death rate on BE | Max death rate (h-1) | εmaxE,E | 1.10 | - | This study |
| Half maximal effective concentration (mg.L-1) | EC50E,E | 3.42 | - | ||
| Hill coefficient | HE,E | 0.67 | - | ||
| Erythromycin-induced death rate on BT | Max death rate (h-1) | εmaxE,T | 3.91 | - | |
| Half maximal effective concentration (mg.L-1) | EC50E,T | 9.26 | - | ||
| Hill coefficient | HE,T | 0.22 | - | ||
| Erythromycin-induced death rate on BET | Max death rate (h-1) | εmaxE,ET | 0.95 | - | |
| Half maximal effective concentration (mg.L-1) | EC50E,ET | 2.47 | - | ||
| Hill coefficient | HE,ET | 0.79 | - | ||
| Tetracycline-induced death rate on BE | Max death rate (h-1) | εmaxT,E | 5.40 | - | |
| Half maximal effective concentration (mg.L-1) | EC50T,E | 81.43 | - | ||
| Hill coefficient | HT,E | 0.30 | - | ||
| Tetracycline-induced death rate on BT | Max death rate (h-1) | εmaxT,T | 1.66 | - | |
| Half maximal effective concentration (mg.L-1) | EC50T,T | 7.27 | - | ||
| Hill coefficient | HT,T | 2.41 | - | ||
| Tetracycline-induced death rate on BET | Max death rate (h-1) | εmaxT,ET | 1.58 | - | |
| Half maximal effective concentration (mg.L-1) | EC50T,ET | 4.42 | - | ||
| Hill coefficient | HT,ET | 1.70 | - | ||