Figure 2.

Human neuroimaging circuitry involved in eating disorders. (A) Represents the structures comprising two major dopaminergic pathways, mesolimbic and mesocortical pathways, supported by prior work in animal models. Both originate in the ventral tegmental area (red); mesolimbic pathways project to the nucleus accumbens, and is part of the complex circuit involving the amygdala (pink), hippocampus (green), and the bed nucleus of the stria terminalis (yellow). The mesocortical pathway projects primarily to the prefrontal cortex (orange) and insula (purple). (B) Represents sub-structures involved in the cortico-striatal-thalamo-cortical (CSTC) pathway that are supported by recent genetic/GWAS studies with shared functional networks that exhibit overlapping phenotypes. The CSTC pathway is a multi-synaptic neuronal circuit that connects the cortex with the striatum and thalamus. The striatum (green) receives glutamatergic input from the cortex and the thalamus (blue) sends out GABAergic inputs to the sub-thalamic nucleus (pink, purple, red).