Table 2.

Baseline correlations between MRI measures and clinical cardiopulmonary variables in MS patients

		VO2max	HRR	HRrest	MWT6	T25FW
T2-hyperintense WM LV	r-value	0.057	− 0.010	− 0.162	− 0.0204	0.094
	p-value	0.668	0.941	0.220	0.125	0.506
NGMV	r-value	0.245	0.052	0.170	0.259	− 0.164
	p-value	0.077	0.714	0.199	0.061	0.240
Left Insula T2-hyperintense LV	r-value	− 0.219	0.268	− 0.079	− 0.028	0.038
	p-value	0.098	0.042	0.551	0.837	0.791
Right Insula T2-hyperintense LV	r-value	0.074	0.230	− 0.123	0.081	0.112
	p-value	0.579	0.083	0.354	0.547	0.430
Left Insula volume	r-value	− 0.480	0.239	0.047	− 0.40	0.148
	p-value	0.719	0.071	0.723	0.768	0.294
Right Insula volume	r-value	− 0.069	0.207	0.054	− 0.046	0.148
	p-value	0.606	0.119	0.687	0.743	0.294

Statistically significant comparisons are shown in bold

bpm beats per minute, HRrest heart rate at rest, HRR heart rate reserve, IQR interquartile range, Kg kilograms, min minutes, mL milliliters, MS-A Multiple sclerosis (MS) patients that performed aerobic training, MS-C MS group that performed motor control training without direct involvement of cardiopulmonary system, MS-WL-A MS patients with baseline insula lesions that performed aerobic training, MS-WOL-A MS patients without baseline insula lesions that performed aerobic training, MS-WL-C MS patients with baseline insula lesions that performed motor control training, MS-WOL-C MS patients without baseline insula lesions that performed motor control training, WM white matter, NGMV normalized gray matter volume, T25FW timed 25-foot walk test, VO2max maximal oxygen consumption, 6MWT six-minute walk test