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. Author manuscript; available in PMC: 2023 Jun 2.
Published in final edited form as: Nat Metab. 2022 Jun 2;4(5):524–533. doi: 10.1038/s42255-022-00565-1

Extended Data Fig. 2 |. Mesaconate and itaconate exhibit different metabolic impacts in macrophages.

Extended Data Fig. 2 |

a. Intracellular metabolite levels of glycolysis and TCA cycle in human monocyte-derived macrophages pre-treated with 10 mM itaconate or mesaconate for 4 h prior to LPS stimulation for 3 h. b,c. Unnormalized oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) from the experiment shown in Fig. 2e. Data are presented as mean ± SEM, and figures are representative of 3 independent experiments.