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. Author manuscript; available in PMC: 2022 Dec 12.
Published in final edited form as: Biochem Pharmacol. 2022 May 10;201:115080. doi: 10.1016/j.bcp.2022.115080

Fig. 13.

Fig. 13.

Amodiaquine (AQ) was metabolized to de-ethyl-amodiaquine (DEAQ) or the glutathione adduct (AQ-SG) in rat liver. MALDI-MSI with a 25 μm spatial resolution reveals zonation patterns in the liver lobule at different time points after a single 100 mg/kg oral dose. The distribution of AQ (green) and DEAQ (red) at 0.5, 1, 2, 5, and 8 h time points varied. Arrow indicates the central veins; * indicates a portal triad region. Adapted with permission from Grove, et al. 2018. Copyright 2022.