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. 2022 Mar 3;21(4):e12794. doi: 10.1111/gbb.12794

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© 2022 The Authors. Genes, Brain and Behavior published by International Behavioural and Neural Genetics Society and John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Learning and memory performance of male and female 5xFAD mice at 12 months of age. (A–F) Performance of WT and 5xFAD mice on measures of learning (latency, distance and cumulative search error), shown separately for males (left) and females (right). Performance is shown for both acquisition (A1‐3) and reversal training (R1‐3), separated by a dashed line. (G,H) Memory performance during the probe trial for male and female 5xFAD and WT mice as measured by percent time in pool quadrants. Dashed line represents time in quadrants expected by chance (25%). Swim‐speed during acquisition and reversal training, along with distance traveled during visible platform training for (I) male and (J) female WT and 5xFAD mice. #, sex difference, p < 0.05; , genotype difference, p < 0.05

Inline graphic — Learning and memory performance of male and female 5xFAD mice at 12 months of age. (A–F) Performance of WT and 5xFAD mice on measures of learning (latency, distance and cumulative search error), shown separately for males (left) and females (right). Performance is shown for both acquisition (A1‐3) and reversal training (R1‐3), separated by a dashed line. (G,H) Memory performance during the probe trial for male and female 5xFAD and WT mice as measured by percent time in pool quadrants. Dashed line represents time in quadrants expected by chance (25%). Swim‐speed during acquisition and reversal training, along with distance traveled during visible platform training for (I) male and (J) female WT and 5xFAD mice. #, sex difference, p < 0.05; , genotype difference, p < 0.05