FIGURE 6.

Age‐related changes in learning and memory performance of male and female 5xFAD and WT mice on the MWM. (A–F) Age‐related changes in learning performance of WT and 5xFAD mice (latency, distance and cumulative search error), shown separately for males (left) and females (right). Performance is shown for the last day of reversal training. (G,H) Memory performance during the probe trial for male and female 5xFAD and WT mice from 3 to 15 months of age, as measured by percent time in the correct pool quadrant. Dashed line represents time in quadrants expected by chance (25%). Swim‐speed during reversal training, for (I) male and (J) female WT and 5xFAD from 3 to 15 months of age. *p < 0.05, compared to 3 months of age