FIGURE 2.

Preliminary conceptual model for SCD pain. Solid colored arrows indicate increased likelihood of pain or worsening prognosis. Dashed colored lines indicate factors that inhibit pain, or are beneficial by decreasing likelihood of pain occurrence. Double‐headed arrows indicate the interaction and interplay between domains (as in the examples of Psychosocial/Behavioral or Biological/Behavioral). Genomics (Biological/Clinical domain) has both solid colored arrows and dashed colored lines because specific genotypes, haplotypes, or genes are associated with either increases in severity of pain or reduction/mitigation of pain