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. 2020 Aug 10;1(1):e10025. doi: 10.1002/ggn2.10025

FIGURE 4.

FIGURE 4

The stemness‐function model. This model posits the existence of two types of environment in an organism: the pro‐stemness state in the early life and regenerating cells, and probiological function in most tissues in the adult stage. Mild global activation of pro‐stemness genes in the pro‐function state may extend lifespan, whereas global overexpression of pro‐stemness genes may result in a detrimental effect