Table 2.
Standard thromboelastometric tests in patients with chronic liver disease and healthy controls (anova with bonferroni adjustment)
| Healthy Controls (CON; a; N = 21 | Acute Decompensation (AD; b; N = 20 |
Acute-On-Chronic Liver Disease (ACLF; c; N = 10 |
P-values | |
|---|---|---|---|---|
|
EXTEM (Reference Ranges) | ||||
| CT (38–79 s) | 55 (51–60) | 62 (56–74) | 71 (64–77) | < 0.05, a vs. b and c |
| CFT (34–159 s) | 80 (72–92) | 146 (100–181) | 139 (94–214) | < 0.05, a vs. b and c |
| TT20 (CT + CFT) | 141 (126–149) | 221 (159–255) | 205 (168–281) | < 0.01, a vs. b and c |
| ALPHA (63–83˚) | 74 (71–75) | 67 (59–74) | 65 (56–71) | < 0.05, a vs. b and c |
| A5 | 48 (43–52) | 32 (28–38) | 30 (19–39) | < 0.01, a vs. b and c |
| A10 (43–65 mm) | 58 (54–60) | 43 (37–48) | 44 (35–54) | < 0.01, a vs. b and c |
| MCF (50–72 mm) | 65 (63–67) | 52 (48–57) | 53 (46–57) | < 0.01, a vs. b and c |
| G | 9108 (8534–10,267) | 5402 (4661–6759) | 5923 (4476–7880) | < 0.01, a vs. b and c |
| TPI | 2.33 (1.82–2.81) | 0.69 (0.53–1.30) | 0.84 (0.42–1.37) | < 0.01, a vs. b and c |
|
INTEM (Reference Ranges) | ||||
| CT (100–240 s) | 182 (167–184) | 190 (163–218) | 215 (194–247) | ns |
| CFT (30–110 s) | 67 (61–83) | 138 (103–172) | 136 (93–213) | < 0.01, a vs. b and c |
| TT20 (CT + CFT) | 255 (239–275) | 326 (306–349) | 369 (312–442) | < 0.01, a vs. b and c |
| ALPHA (70–83˚) | 76 (73–77) | 67 (60–71) | 62 (55–70) | < 0.01, a vs. b and c |
| A5 | 46 (42–49) | 33 (28–37) | 32 (24–38) | < 0.01, a vs. b and c |
| A10 (44–66 mm) | 57 (54–59) | 43 (37–47) | 41 (33–47) | < 0.01, a vs. b and c |
| MCF (50–72 mm) | 62 (61–65) | 50 (45–56) | 51 (43–55) | < 0.01, a vs. b and c |
| G | 8322 (7988–9442) | 5278 (4313–6558) | 5192 (3918–6360) | ns |
| TPI | 2.43 (1.79–3.04) | 0.72 (0.51–1.11) | 0.80 (0.35–1.30) | < 0.01, a vs. b and c |
| CT-Ratio (INTEM/HEPTEM) | 1.04 (0.95–1.08) | 0.96 (0.89–1.07) | 1.03(1.01–1.25) | ns |
|
FIBTEM (Reference Ranges) | ||||
| CT | 52 (49–57) | 61 (50–67) | 61 (51–77) | ns |
| A5 | 16 (12–17) | 14 (10–16) | 10 (8–14) | ns |
| A10 (7–23 mm) | 16 (13–19) | 14 (11–16) | 10 (8–16) | ns |
| MCF (9–25 mm) | 17 (14–19) | 15 (12–18) | 11 (9–17) | ns |
| Velocity parameter | ||||
| EXTEM AUC | 6446 (6263–6731) | 5152 (4777–5692) | 5405 (4705–6049) | < 0.01, a vs. b and c |
| EXTEM maxV | 15 (13–17) | 11 (8–14) | 10 (8–14) | < 0.01, a vs. b and c |
| EXTEM maxV-t | 103 (73–118) | 92 (63–145) | 105 (85–129) | ns |
| FIBTEM AUC | 1699 (1409–2161) | 1532 (1206–1817) | 1095 (965–1601) | ns |
| FIBTEM maxV | 14 (11–16) | 10 (8–16) | 8 (6–11) | ns |
| FIBTEM maxV-t | 58 (53–69) | 66 (61–77) | 72 (60–80) | ns |
| INTEM AUC | 6257 (6082–6427) | 5178 (4662–5687) | 5241 (4395–5618) | < 0.01, a vs. b and c |
| INTEM maxV | 18 (15–20) | 11 (9–13) | 10 (7–13) | < 0.01, a vs. b and c |
| INTEM maxV-t | 205 (193–224) | 205 (180–243) | 254 (214–288) | 0.05, b vs. c |
| Fibrinoliysis parameter | ||||
| EXTEM LI30 (94–100%) | 100 (100–100) | 100 (100–100) | 100 (100–100) | ns |
| EXTEM LI45 | 97 (96–98) | 99 (96–100) | 100 (99–100) | < 0.05 a vs. c |
| EXTEMLI60 (86–100%) | 93 (90–96) | 96 (91–98) | 99 (96–100) | < 0.05 a vs. c |
| EXTEM ML (< 15% at 60 min after CT) | 7.0 (4.0–9.0) | 4.0 (2.0–8.5) | 1.0 (0.0–3.2) | < 0.05 a vs. c |
| FIBTEM LI30 | 100 (100–100) | 100 (99–100) | 100 (97–100) | ns |
| FIBTEM LI45 | 100 (100–100) | 100 (98–100) | 100 (97–100) | ns |
| FIBTEM LI60 | 100 (99–100) | 100 (97–100) | 100 (96–100) | ns |
| FIBTEM ML | 0 (0–0.5) | 0 (0–2.5) | 0 (0–3.5) | ns |
| ΔLI60 (FIBTEM – EXTEM) | 6(4–9) | 2.5(1–6.7) | 0.5(-2.7–3.2) | < 0.05 a vs. c |