Table 3.
Thromboelastometric tests without and with Protac® challenge in patients with chronic liver disease and healthy controls
| Without Protac | With Protac | P-value | Ratio w/who Protac | |
|---|---|---|---|---|
| Healthy controls (N = 21) | ||||
| EXTEM | ||||
| CT | 55 (51–60) | 66 (53–77) | 0.02 | 1.2 |
| CFT | 80 (72–92) | 92 (80–108) | 0.01 | 1.1 |
| TT20 (CT + CFT) | 141 (126–149) | 163 (140–183) | 0.003 | 1.1 |
| ALPHA | 74 (71–75) | 72 (69–74) | 0.03 | 0.9 |
| A5 | 48 (43–52) | 44 (41–48) | 0.01 | 0.9 |
| A10 | 58 (54–60) | 55 (53–59) | 0.02 | 0.9 |
| MCF | 65 (63–67) | 65 (62–68) | 0.59 | 1.0 |
| G | 9108 (8534–10,267) | 9511 (8507–10,735) | 0.25 | 1.0 |
| TPI | 2.33 (1.82–2.81) | 2.04 (1.54–2.61) | 0.17 | 0.9 |
| INTEM | ||||
| CT | 182 (167–194) | 180 (157–199) | 0.66 | 0.9 |
| CFT | 67 (61–83) | 81 (72–97) | 0.009 | 1.1 |
| CT + CFT (TT20) | 255 (239–275) | 255 (247–288) | 0.38 | 1.0 |
| ALPHA | 76 (73–77) | 73 (71–75) | 0.03 | 0.9 |
| A5 | 46 (42–49) | 45 (43–48) | 0.36 | 0.9 |
| A10 | 57 (54–59) | 56 (53–58) | 0.43 | 0.9 |
| MCF | 62 (61–65) | 62 (60–66) | 0.57 | 1.0 |
| G | 8322 (7988–9442) | 9210 (8193–9797) | 0.28 | 1.0 |
| TPI | 2.43 (1.79–3.04) | 2.02 (1.68–2.34) | 0.10 | 0.9 |
| FIBTEM | ||||
| CT | 52 (49–57) | 59 (54–67) | 0.01 | 1.1 |
| A5 | 16 (12–17) | 14 (13–16) | 0.22 | 0.9 |
| A10 | 16 (13–19) | 15 (14–18) | 0.42 | 0.9 |
| MCF | 17 (14–19) | 16 (15–19) | 0.57 | 0.9 |
| Velocity parameter | ||||
| EXTEM AUC | 6446 (6263–6731) | 6518 (6262–6819) | 0.54 | 1.0 |
| EXTEM maxV | 15 (13–17) | 14 (11–17) | 0.25 | 0.9 |
| EXTEM maxV-t | 103 (73–118) | 127 (87–146) | 0.03 | 1.2 |
| FIBTEM AUC | 1699 (1409–2161) | 1601 (1463–1798) | 0.09 | 0.9 |
| FIBTEM maxV | 14 (11–16) | 12 (9–15) | 0.19 | 0.9 |
| FIBTEM maxV-t | 58 (53–69) | 74 (59–85) | 0.06 | 1.3 |
| INTEM AUC | 6257 (6082–6427) | 6454 (6278–6657) | 0.02 | 1.0 |
| INTEM maxV | 18 (15–20) | 17 (15–18) | 0.21 | 1.3 |
| INTEM maxV-t | 205 (193–224) | 229 (199–250) | 0.23 | 1.0 |
| Fibrinolysis parameter | ||||
| EXTEM LI30 | 100 (100–100) | 100 (100–100) | 0.10 | 1.0 |
| EXTEM LI45 | 97 (96–98) | 100 (98–100) | < 0.001 | 1.0 |
| EXTEM LI60 | 93 (90–96) | 98 (95–99) | < 0.001 | 1.0 |
| EXTEM ML | 7 (4–9) | 2 (1–5) | < 0.001 | 0.3 |
| FIBTEM LI30 | 100 (100–100) | 98 (100–100) | 0.12 | 0.9 |
| FIBTEM LI45 | 100 (100–100) | 97 (100–100) | 0.10 | 0.9 |
| FIBTEM LI60 | 100 (99–100) | 100 (100–100) | 0.53 | 0.9 |
| FIBTEM ML | 0 (0–0.5) | 0 (0–3.5) | 0.53 | 0.8 |
| Acute Decompensated Patients (AD; N = 20) | ||||
| EXTEM | ||||
| CT | 62 (56–74) | 63 (55–75) | 0.67 | 1.0 |
| CFT | 146 (100–181) | 136 (113–169) | 0.49 | 1.0 |
| TT20 (CT + CFT) | 221 (159–255) | 198 (173–248) | 0.77 | 1.0 |
| ALPHA | 67 (59–74) | 67 (63–70) | 0.54 | 1.0 |
| A5 | 32 (28–38) | 33 (29–38) | 0.60 | 1.0 |
| A10 | 43 (37–48) | 44 (39–47) | 0.46 | 0.9 |
| MCF | 52 (48–57) | 52 (48–56) | 0.61 | 0.9 |
| G | 5402 (4661–6759) | 5624 (4738–6519) | 0.50 | 1.0 |
| TPI | 0.69 (0.53–1.30) | 0.80 (0.61–1.04) | 0.27 | 1.0 |
| INTEM | ||||
| CT | 190 (163–218) | 212 (166–237) | 0.02 | 1.1 |
| CFT | 138 (103–172) | 106 (88–152) | 0.067 | 0.9 |
| TT20 (CT + CFT) | 326 (306–349) | 312 (278–348) | 0.73 | 1.0 |
| ALPHA | 67 (60–71) | 70 (62–72) | 0.43 | 1.0 |
| A5 | 33 (28–37) | 35 (29–38) | 0.79 | 1.0 |
| A10 | 43 (37–47) | 44 (39–47) | 0.74 | 1.0 |
| MCF | 50 (45–56) | 50 (47–56) | 0.72 | 1.0 |
| G | 5278 (4313–6558) | 5595 (4445–6604) | 0.61 | 1.0 |
| TPI | 0.72 (0.51–1.11) | 1.02 (0.59–1.33) | 0.48 | 1.5 |
| FIBTEM | ||||
| CT | 61 (50–67) | 65 (58–72) | 0.03 | 1.0 |
| A5 | 14 (10–16) | 12 (8–16) | 0.06 | 0.8 |
| A10 | 14 (11–16) | 13 (9–17) | 0.07 | 0.9 |
| MCF | 15 (12–18) | 13 (9–17) | 0.11 | 0.9 |
| Velocity parameter | ||||
| EXTEM AUC | 5152 (4777–5692) | 5191 (4851–5590) | 0.47 | 0.9 |
| EXTEM maxV | 11 (8–14) | 10 (9–12) | 0.35 | 0.9 |
| EXTEM maxV-t | 92 (63–145) | 85 (68–155) | 0.38 | 1.2 |
| FIBTEM AUC | 1532 (1206–1817) | 1340 (841–1652) | 0.01 | 0.8 |
| FIBTEM maxV | 10 (8–16) | 10 (8–14) | 0.08 | 0.8 |
| FIBTEM maxV-t | 66 (61–77) | 69 (64–79) | 0.40 | 1.0 |
| INTEM AUC | 5178 (4662–5687) | 5239 (4976–5670) | 0.57 | 0.9 |
| INTEM maxV | 11 (9–13) | 11 (10–13) | 0.51 | 1.0 |
| INTEM maxV-t | 205 (180–243) | 215 (196–256) | 0.05 | 1.0 |
| Fibrinolysis parameter | ||||
| EXTEM LI30 | 100 (100–100) | 100 (100–100) | 0.31 | 1.0 |
| EXTEM LI45 | 99 (96–100) | 100 (99–100) | 0.06 | 1.0 |
| EXTEM LI60 | 96 (91–98) | 97 (95–98) | 0.02 | 1.0 |
| ML EXTEM | 4.0 (2.0–8.5) | 2.5 (2.0–4.7) | 0.02 | 0.7 |
| FIBTEM LI30 | 100 (99–100) | 100 (100–100) | 0.49 | 0.9 |
| FIBTEM LI45 | 100 (98–100) | 100 (100–100) | 0.48 | 0.9 |
| FIBTEM LI60 | 100 (97–100) | 100 (98–100) | 0.48 | 0.9 |
| ML FIBTEM | 0 (0–2.5) | 0 (0–1.5) | 0.48 | 0.5 |
| Acute-On-Chronic Liver Failure Patients (ACLF, N = 10) | ||||
| EXTEM | ||||
| CT | 71 (64–77) | 64 (54–76) | 0.28 | 0.9 |
| CFT | 139 (94–214) | 159 (98–251) | 0.95 | 1.0 |
| TT20 (CT + CFT) | 205 (168–281) | 221 (160–334) | 0.50 | 1.0 |
| ALPHA | 65 (56–71) | 62 (57–72) | 0.85 | 1.0 |
| A5 | 30 (19–39) | 35 (22–47) | 0.41 | 0.9 |
| A10 | 44 (35–54) | 41 (31–52) | 0.72 | 0.9 |
| MCF | 53 (46–57) | 51 (41–60) | 0.85 | 1.0 |
| G | 5923 (4476–7880) | 5380 (3617–7748) | 0.50 | 0.9 |
| TPI | 0.84 (0.42–1.37) | 0.69 (0.29–1.64) | 0.87 | 1.1 |
| INTEM | ||||
| CT | 215 (194–247) | 212 (187–238) | 0.61 | 0.9 |
| CFT | 136 (93–213) | 119 (76–207) | 0.02 | 0.9 |
| TT20 (CT + CFT) | 369 (312–442) | 331 (260–458) | 0.16 | 0.9 |
| ALFA | 62 (55–70) | 67 (61–72) | 0.04 | 1.0 |
| A5 | 32 (24–38) | 33 (24–40) | 0.59 | 1.0 |
| A10 | 41 (33–47) | 41 (32–49) | 0.71 | 0.9 |
| MCF | 51 (43–55) | 51 (41–56) | 0.71 | 0.9 |
| G | 5192 (3918–6360) | 5144 (3541–6784) | 0.72 | 1.0 |
| TPI | 0.80 (0.35–1.30) | 1.01 (0.34–1.50) | 0.01 | 1.1 |
| FIBTEM | ||||
| CT | 61 (51–77) | 65 (54–85) | 0.30 | 1.1 |
| A5 | 10 (8–14) | 10 (6–15) | 0.36 | 0.9 |
| A10 | 10 (8–16) | 11 (6–16) | 0.57 | 0.9 |
| MCF | 11 (9–17) | 12 (9–18) | 0.59 | 1.9 |
| Velocity parameter | ||||
| EXTEM AUC | 5405 (4705–6049) | 5145 (4194–6064) | 0.57 | 0.9 |
| EXTEM maxV | 10 (8–14) | 9 (7–13) | 0.85 | 1.0 |
| EXTEM maxV-t | 105 (85–129) | 103 (57–144) | 0.95 | 1.1 |
| FIBTEM AUC | 1095 (965–1601) | 1244 (712–1776) | 0.87 | 1.0 |
| FIBTEM maxV | 8 (6–11) | 10 (4–15) | 1.00 | 1.0 |
| FIBTEM maxV-t | 72 (60–80) | 71 (63–89) | 0.33 | 1.1 |
| INTEM AUC | 5241 (4395–5618) | 5028 (4140–5719) | 0.50 | 0.9 |
| INTEM maxV | 10 (7–13) | 9 (7–15) | 0.30 | 1.0 |
| INTEM maxV-t | 254 (214–288) | 265 (222–286) | 0.67 | 0.9 |
| Fibrinolysis parameter | ||||
| EXTEM LI30 | 100 (100–100) | 100 (100–100) | 1.00 | 1.0 |
| EXTEM LI45 | 100 (99–100) | 100 (99–100) | 0.10 | 1.0 |
| EXTEM LI60 | 99 (96–100) | 99 (97–100) | 0.04 | 1.0 |
| EXTEM ML | 1.0 (0.0–3.2) | 0.5 (0.0–2.2) | 0.02 | 0.4 |
| FIBTEM LI30 | 100 (97–100) | 100 (94–100) | 0.71 | 0.9 |
| FIBTEM LI45 | 100 (97–100) | 100 (90–100) | 0.46 | 0.9 |
| FIBTEM LI60 | 100 (96–100) | 100 (96–100) | 0.71 | 0.9 |
| FIBTEM ML | 0.0 (0.0–3.5) | 0.0 (0.0–14) | 0.71 | 0.5 |