Table 5.
ROC curve analyses for combined ROTEM parameters to identify the coagulation pattern of patients with chronic liver disease and healthy controls
| ROTEM parameter | ROC AUC | 95% CI | P-VALUE |
OPTIMUM CUT-OFF |
SENS | SPEC | PPV | NPV |
|---|---|---|---|---|---|---|---|---|
| Healthy Controls (CON) vs. Liver Disease Patients (AD + ACLF) | ||||||||
| EXTEM TT20 + INTEM CFT | 0.944 | 0.884–1.000 | < 0.001 | 0.254 | 96% | 72% | 83% | 94% |
| EXTEM TT20 + EXTEM LI60 | 0.913 | 0.827–0.998 | < 0.001 | 0.319 | 90 | 66 | 79 | 82 |
| INTEM CFT + EXTEM LI60 | 0.927 | 0.852–1.00 | < 0.001 | 0.329 | 90 | 89 | 87 | 85 |
| EXTEM TT20 + INTEM CFT + EXTEM LI60 | 0.943 | 0.876–1.00 | < 0.001 | 0.678 | 83 | 100 | 100 | 81 |
| EXTEM TT20 – EXTEM A5 | 0.902 | 0.812–0.991 | < 0.001 | 106 | 86 | 81 | 87 | 81 |
| EXTEM TT20 / EXTEM A5 | 0.896 | 0.825–0.987 | < 0.001 | 4.11 | 80 | 100 | 100 | 78 |
| EXTEM TT20 / (EXTEM A5 x EXTEM ML) | 0.881 | 0.775–0.987 | < 0.001 | 0.780 | 80 | 85 | 87 | 78 |
| INTEM CFT – INTEM A5 | 0.929 | 0.853–1.000 | < 0.001 | 45.5 | 90 | 85 | 90 | 86 |
| INTEM CFT / INTEM A5 | 0.929 | 0.855–1.000 | < 0.001 | 2.571 | 80 | 95 | 96 | 77 |
| INTEM CFT – 10 × INTEM TPI | 0.926 | 0.850–1.000 | < 0.001 | 67.6 | 90 | 85 | 87 | 85 |
| INTEM CFT / INTEM TPI | 0.925 | 0.849–1.000 | < 0.001 | 50.1 | 90 | 81 | 87 | 85 |
| EXTEM TT20 + EXTEM ML-ratio | 0.929 | 0.852–1.000 | < 0.001 | 0.571 | 80 | 90 | 91 | 79 |
| EXTEM TT20 x EXTEM ML-ratio | 0.778 | 0.639–0.918 | 0.001 | 53.21 | 80 | 58 | 94 | 67 |
| INTEM CFT – INTEM ΔCFT | 0.895 | 0.802–0.988 | < 0.001 | 87.5 | 86 | 85 | 90 | 82 |
| INTEM CFT / EXTEM LI60-ratio | 0.948 | 0.893–1.000 | < 0.001 | 89 | 90 | 85 | 90 | 82 |
| INTEM CFT / EXTEM A5 x EXTEM LI60-ratio | 0.947 | 0.885–1.000 | < 0.001 | 2 | 90 | 85 | 87 | 89 |
| INTEM CFT + EXTEM ML-ratio | 0.947 | 0.887–1.000 | < 0.001 | 0.587 | 80 | 95 | 95 | 80 |
| INTEM CFT x EXTEM ML-ratio | 0.919 | 0.841–0.998 | < 0.001 | 97.39 | 80 | 90 | 100 | 63 |
| INTEM CFT-ratio + EXTEM LI60-ratio | 0.879 | 0.779–0.979 | < 0.001 | 0.711 | 80 | 95 | 96 | 77 |
| INTEM CFT-ratio x EXTEM LI60-ratio | 0.170 | 0.045–0.295 | < 0.001 | 0.662 | 80 | 0.04 | 56 | 17 |
| 1 / (INTEM CFT-ratio + EXTEM LI60-ratio) | 0.121 | 0.021–0.221 | < 0.001 | 1.211 | 43 | 0.04 | 39 | 6 |
| 1 / (INTEM CFT-ratio x EXTEM LI60-ratio) | 0.838 | 0.720–0.956 | < 0.001 | 0.973 | 80 | 85 | 59 | 41 |
| AD vs. ACLF | ||||||||
| INTEM maxV-t – EXTEM ML | 0.745 | 0.555–0.935 | 0.031 | 219 | 80 | 65 | 53 | 87 |
| INTEM maxV-t / EXTEM ML | 0.744 | 0.508–0.981 | 0.060 | 49 | 85 | 58 | 43 | 92 |
| INTEM maxV-t + EXTEM LI60 | 0.81 | 0.636–0.984 | 0.006 | 0.324 | 80 | 70 | 57 | 87 |
| INTEM maxV-t x EXTEM LI60 | 0.750 | 0.564–0.936 | 0.028 | 21,481 | 80 | 65 | 53 | 87 |
| INTEM maxV-t – INTEM ΔCFT | 0.713 | 0.531–0.894 | 0.062 | 191 | 90 | 55 | 37 | 83 |