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Core targets of PPI and compound-target-pathway network.
| Target | PPI degree | Compound-target-pathway degree |
|---|---|---|
| IL6 | 63 | 11 |
| MAPK3 | 59 | 9 |
| CASP3 | 58 | 15 |
| TNF | 57 | 13 |
| MAPK8 | 57 | 10 |
| CYCS | 50 | 7 |
| MAPK1 | 49 | 9 |
| IL1B | 49 | 9 |
| CXCL8 | 46 | 10 |
| CCL2 | 43 | 6 |
| CASP8 | 40 | 12 |
| MAPK14 | 40 | 9 |
| RELA | 39 | 15 |
| FOS | 38 | 10 |
| CASP9 | 37 | 8 |
| NFKBIA | 33 | 7 |
| NFKB1 | 32 | 13 |
| NOS2 | 32 | 18 |
| FASLG | 32 | 6 |
| CYP2E1 | 31 | 6 |
| CYP3A4 | 31 | 6 |
