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. Author manuscript; available in PMC: 2022 Dec 12.
Published in final edited form as: Curr Opin Microbiol. 2021 Aug 5;63:172–178. doi: 10.1016/j.mib.2021.07.008

Figure 1.

Figure 1

A generic negative feedback affecting the uptake of carbon substrates. A carbon substrate is taken up and catabolized through transporters and catabolic enzymes, grouped as “C”. The precursors derived from the substrate through catabolism are utilized for biosynthesis through biosynthetic enzymes including ribosomes, grouped as “A”. The difference between the fluxes through C and A is read out as the activity of cAMP-Crp, which is necessary for the expression of substrate uptake systems. If the flux through C is in excess, cAMP-Crp activity and thereby the substrate uptake is reduced [7].