Figure 4. Identification of diagnostic signature for CAD by LASSO and RF algorithms.

(A) LASSO regression of the 53 M2 macrophage-related DEGs (left). Cross-validation for tuning the parameter selection in the LASSO regression (right). (B) Evaluation and validation of LASSO diagnostic model by ROC curves. (C) Importance of genetic variables in RF models. (D) Evaluation of RF diagnostic model by ROC curve.