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. 2022 Dec 12;13:7670. doi: 10.1038/s41467-022-35357-4

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Spearman correlation (the size and color of the square represent the Spearman Rho; significance levels are depicted by stars) between five measured clinical outcomes and two CSF biomarker-predicted multiple sclerosis (MS) severity outcomes in the validation cohort (N = 98). b Correlations between prospectively measured MS progression slopes (i.e., therapy adjusted CombiWISE slopes derived from longitudinal clinical follow-up; y-axes), clinical/imaging outcomes and CSF biomarker-predicted outcomes (x-axes). For exact Spearman Rho, p-values, and R² see Supplementary Data 8. MS-DSS Multiple Sclerosis Disability Severity Score, MSSS Multiple Sclerosis Severity Score, ARMSS Age-Related Multiple Sclerosis Severity, CombiWISE Combinatorial weight-adjusted disability score, sNFL serum neurofilament light chain, cNFL CSF neurofilament light chain. All statistical tests were two-sided. Source data are provided as a Source Data file.