Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic overview of inflammasome activation. Various PAMPs and DAMPs induce activation of sensor proteins resulting in oligomerization and recruitment of ASC and pro-CASP1. Upon autoproteolysis of pro-CASP1, mature CASP1 cleaves the inflammasome effector molecules pro-IL-1β, pro-IL-18, and GSDMD, which induce inflammation and pyroptosis.
