TABLE 1.

Comparison of basic physiological characteristics of three kinds of EVs.

Characteristics	Exosome	Microvesicles	Apoptotic bodies
General characteristics	Almost all cells can secrete
	Presented in body fluids
	Rich in protein, lipid and genetic material
Biogenesis mechanism	Endocytosis and exocytosis, Generated by multi vesicle system	Cell membrane budding	Release during apoptosis
Diameter	30‐150 nm	50‐1000 nm	1000‐5000 nm
Main markers	Transmembrane protein (CD9, CD63, CD81)TSG101, Lactadherin, LAMP1	CD40PhosphatidylserineCell surface antigen	Phosphatidylserine