Table 1.

Animal Models of NASH-HCC Induced by Different Diets and Toxins

Diet	Toxic Agent	Metabolic Syndrome	HCC Development	References
HFD	No	No	No	9
Western diet	No	No	No	12
MCD	No	Yes	No	12; 13; 14
HFD+MCD	No	Yes	Yes (25%)	16
American fast-food diet (ALIOS model)	No	Yes	Yes	17; 18; 19
HFD	Streptozoticin	Diabetes Type 1	Yes	20
HFD	DEN	Yes	Yes	21
Western diet	CCl4	No	Yes	22

Abbreviations: HFD, high-fat diet; MCD, methionine- and choline-deficient diet; DEN, diethyl nitrosamine; CCl₄, carbon tetrachloride.