Table 2.

Shows 11 out of 43 proteolysis associated genes that are implicated in male reproduction.

Gene	Function/Phenotype	Reference
Prss37	Serine protease, defective sperm migration and sperm-egg interaction	23
Prss55	Serine protease, defective sperm migration in utero	24
Adam1a	Zinc metalloprotease, defective sperm migration in utero	25
Adam24	Metalloproteinase on sperm surface, polyspermic embryos at the pronuclear stage resulting in reduced fertility	26
Adam26a	Thought to play a role in spermatogenesis	27
Cops5	protease subunit of COP9 signalosome complex, acts as the catalytic center of the de-neddylation activity of cullins. Mutation leas to embryo growth arrest	28
Mmel1	Metalloendopeptidase, deficiency leads to impaired fertilization and aberrant embryo development	29
Immp2l	Inner mitochondrial membrane peptidase 2-like is required for signal peptide sequence processing of proteins that require mitochondrial import. The mutated gene disturbs the inner mitochondrial proteostasis and results in female and male infertility	30
Sppl2c	Signal peptide peptidase. Disruption leads to a partial loss of elongated spermatids, reduced motility and reduced litter sizes when mated with Sppl2c deficient female	31
Psma6	Component of the 20S core proteasome complex, has also been associated with low fertility	32
Usp1	De-ubiquitinating enzyme causes amongst others Fanconi anemia (chromosome instability), which implicates infertility of male mice	33