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. 2022 Dec 12;5:1362. doi: 10.1038/s42003-022-04314-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Western blot analysis of RNF20, H2Bub1, and H2B in FT190 and FT194 treated with two shRNAs targeting RNF20 or a control shRNA. b Venn diagram of the 25 most enriched pathways in FT190 and FT194 cells that were treated with two shRNAs (sh890 or sh692) to knockdown the RNF20 E3 ligase. c Display of the 7 pathways that overlap with all conditions in A. Bar graphs represent the False Discovery Rate (FDR) adjusted p-value in -log10 scale. The color represents percentage of regulated genes in each pathway. d Volcano plot of FT190 cells treated with RNF20 shRNA and analyzed with RPPA. Red dots depict the proteins that are significantly regulated. Orange dots depict samples that are regulated over 0.5 log2 fold (1.4 fold) and green depicts proteins that are significantly and 0.5 log2 fold regulated. e Western blot analysis of L1CAM and beta Actin in FT190 and FT194 treated with two shRNAs targeting RNF20 or a control shRNA.