Table 3.
Antitumor Effects of CNTs in vivo
S. No | Type of CNTs and Dimensions | Drug Load and Route of Administration | Animal Model | Effects or Outcomes | Ref. |
---|---|---|---|---|---|
1. | MWCNTs, diameters of 20 to 30 nm, 0.5 to 2 μm length | Immunoadjuvants and antigenic ovalbumin | C57BL/6 mice | Inhibition of metastatic growth in lungs and improved survival of tumor mice | [43] |
2. | MWCNTs, sizes of 20 to 30 nm | siPLK1, intratumoral region | Female Swiss nude mice |
|
[44] |
3. | MWCNTs, Diameters of 20–30 nm, and lengths of 0.5–2 μm | siPLK1, intratumoral administration | Female CD1 nude mice |
|
[45] |
4. | MWCNTs, length of 974 nm | Subcutaneous administration | Female BALB/c mice | Reduction of macrophages, vessel density and inhibition of metastatic growth in lungs | [46] |
5. | SWCNTs, diameters of 50 nm | Gemcitabine, Intravenous tail injection | B6 athymic nude mice | Decrease in tumor size and improved survival | [40] |