Skip to main content
. 2022 Dec 8;17:6157–6180. doi: 10.2147/IJN.S384592

Table 3.

Antitumor Effects of CNTs in vivo

S. No Type of CNTs and Dimensions Drug Load and Route of Administration Animal Model Effects or Outcomes Ref.
1. MWCNTs, diameters of 20 to 30 nm, 0.5 to 2 μm length Immunoadjuvants and antigenic ovalbumin C57BL/6 mice Inhibition of metastatic growth in lungs and improved survival of tumor mice [43]
2. MWCNTs, sizes of 20 to 30 nm siPLK1, intratumoral region Female Swiss nude mice
  1. Decrease in tumor volume mediated by apoptosis and necrosis

  2. Decline in PLK1 mRNA and protein levels

[44]
3. MWCNTs, Diameters of 20–30 nm, and lengths of 0.5–2 μm siPLK1, intratumoral administration Female CD1 nude mice
  1. Reduction in tumor growth and volume with enhanced survival

  2. Apoptosis and necrosis of tumor cells

[45]
4. MWCNTs, length of 974 nm Subcutaneous administration Female BALB/c mice Reduction of macrophages, vessel density and inhibition of metastatic growth in lungs [46]
5. SWCNTs, diameters of 50 nm Gemcitabine, Intravenous tail injection B6 athymic nude mice Decrease in tumor size and improved survival [40]