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. 2022 Dec 12;13:7677. doi: 10.1038/s41467-022-35469-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Representative subcutaneous tumors (left)/orthotopic transplantation tumors (right) collected from Hepa1-6-bearing C57BL/6 mice. b Tumor proliferation curves of subcutaneous xenografts in Hepa1-6-bearing C57BL/6 mice. Data presented as mean ± SEM. n = 6 mice per group. c Kaplan–Meier survival curves of Hepa1-6-bearing C57BL/6 mice. n = 6 mice per group. d Representative subcutaneous tumors (left)/orthotopic transplantation tumors (right) collected from H22-bearing C57BL/6 mice. e Tumor proliferation curves of subcutaneous xenografts in H22-bearing C57BL/6 mice. Data presented as mean ± SEM. n = 6 mice per group. f Kaplan-Meier survival curves of H22-bearing C57BL/6 mice. n = 6 mice per group. g–i Flow cytometry analysis of CD8⁺, GZMB⁺CD8⁺, and PD1⁺CD8⁺ in CD3⁺ TILs from Hepa1-6 (g) or H22 xenografts (h) in C57BL/6 mice and their quantification (i). Data presented as mean ± SEM. n = 3 mice per group. j Representative subcutaneous tumors (left)/orthotopic transplantation tumors (right) collected from Hepa1-6-bearing BALB/c nude mice. k Tumor proliferation curves of subcutaneous xenografts in Hepa1-6-bearing BALB/c nude mice. Data presented as mean ± SEM. n = 6 mice per group. l Kaplan–Meier survival curves of Hepa1-6-bearing BALB/c nude mice. n = 6 mice per group. m Representative subcutaneous tumors (left)/orthotopic transplantation tumors (right) collected from H22-bearing BALB/c nude mice. n Tumor proliferation curves of subcutaneous xenografts in H22-bearing BALB/c nude mice. Data presented as mean ± SEM. n = 6 mice per group. o Kaplan–Meier survival curves of H22-bearing BALB/c nude mice. n = 6 mice per group. p, q T cell-mediated cancer cell-killing assay results. Data presented as mean ± SEM (n = 3 independent biological replicates). P value was determined by unpaired two-sided Student’s t test with no correction for multiple comparisons (b, e, i, k, n, p, q) and Kaplan-Meier method (c, f, l, o). Schematic diagrams (a, d, j, m) were created with BioRender.com. Source data are provided as a Source data file.