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. 2022 Nov 29;13:1012981. doi: 10.3389/fimmu.2022.1012981

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Copyright © 2022 Cui, Liang, Dai, Cui, Cai, Ding, Ma, Yin, Li, Liu, Kang, Yao, Cen, Shen, Zhu, Yu, Wu and Tang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dynamic changes after CAR-T-38 treatment. (A) The copies of CAR-T-38 cells in the peripheral blood measured by qPCR as the number of copies of lentiviral vector sequence per microgram of genomic DNA, which reached peak levels on days 4 and 6, respectively. (B) The neutrophil counts (left Y-axis) in patients 1 and 2 rose above 0.5 × 10⁹ on days 14 and 7, respectively, and platelet counts (right Y-axis) of the two patients rose above 100 × 10⁹ on day 14. (C) This part showed the changes of cytokines including IL-6, IL-10, TNFα, and IFNγ concentrations after CAR-T-38 infusion. (D) This part showed the changes of c-reaction protein (left Y-axis) and ferritin (right Y-axis) concentrations after CAR-T-38 infusion.