Table 2.
Top 10 significant gene ontology (GO) biological process including differentially expressed gene (DEGs) in the lung of SARS-CoV_2-infected hamsters after inoculation of IFN-λs at 3 and 7 dpi.
| Term | Overlap genes |
|---|---|
| cytokine-mediated signaling pathway (GO:0019221) |
IFITM3, CD86, CXCL9, F13A1, SLA, ADAR, IFI35, IFIT1, IFI30, CXCL2, IFIT3, CXCL5, IL18BP, IFIT2, LMNB1, PYCARD, MT2A, CASP1, TIMP1, CCR5, RSAD2, IFI27, OAS2, OAS3, PSME1, IRF7, BIRC5, IRF8, IRF9, CSF1R, CCL11, PSMD13, PTAFR, CSF2RB, IL2RG, SAMHD1, LRP8, PSMB10, SOCS3, CCL8, SOCS1, CCL7, CCL5, CCL4, HMOX1, CCL2, TNFRSF14, GBP2, FCGR1A, GBP1, CCL25, STAT1, STAT2, MX1, ISG15, PSMB8, PSMB9, VEGFA, BST2, CXCL10, CXCL11, SAA1, CD27 |
| cellular response to type I interferon (GO:0071357) |
IFITM3, RSAD2, STAT1, STAT2, MX1, ADAR, ISG15, IFI35, IFIT1, SAMHD1, IFIT3, PSMB8, IFIT2, BST2, IFI27, OAS2, OAS3, IRF7, IRF8, GBP2, IRF9 |
| type I interferon signaling pathway (GO:0060337) |
IFITM3, RSAD2, STAT1, STAT2, MX1, ADAR, ISG15, IFI35, IFIT1, SAMHD1, IFIT3, PSMB8, IFIT2, BST2, IFI27, OAS2, OAS3, IRF7, IRF8, GBP2, IRF9 |
| defense response to virus (GO:0051607) |
IFITM3, RTP4, IFIT1, SAMHD1, IFI44L, IFIT3, IFIT2, PYCARD, IFIH1, ZBP1, RSAD2, DDX58, STAT1, STAT2, MX1, RNASE6, EIF2AK2, ISG15, BST2, CXCL10, SLFN11, IFI27, OAS2, OAS3, IRF7, TLR7 |
| defense response to symbiont (GO:0140546) |
IFITM3, RTP4, IFIT1, SAMHD1, IFI44L, IFIT3, IFIT2, PYCARD, IFIH1, ZBP1, RSAD2, DDX58, STAT1, STAT2, MX1, RNASE6, EIF2AK2, ISG15, BST2, SLFN11, IFI27, OAS2, OAS3, IRF7, TLR7 |
| cellular response to interferon-gamma (GO:0071346) |
GBP6, CCL25, GBP5, CCL11, STAT1, PTAFR, IFI30, AIF1, MT2A, CCL8, CCL7, OAS2, OAS3, CCL5, CCL4, CASP1, IRF7, IRF8, CCL2, FCGR1A, GBP2, GBP1, IRF9, GBP4 |
| response to interferon-gamma (GO:0034341) |
IFITM3, GBP6, CCL25, GBP5, CCL11, STAT1, SLC11A1, AIF1, BST2, CCL8, CCL7, CCL5, UBD, CCL4, CASP1, IRF8, CCL2, GBP2, GBP1, GBP4 |
| cellular response to cytokine stimulus (GO:0071345) |
CD86, CSF1R, CCL11, PTAFR, F13A1, SLA, CSF2RB, IL2RG, IFIT1, LRP8, AIF1, CXCL2, IL18BP, PYCARD, SOCS3, MT2A, CCL8, SOCS1, CCL7, CCL5, CCL4, CASP1, HMOX1, CCL2, TIMP1, GBP2, CCR5, GBP1, GBP4, GBP6, CCL25, GBP5, STAT1, STAT2, PYHIN1, MAPK13, VEGFA, CXCL10, SAA1, HCLS1, BIRC5, IRF8, CHI3L1, MNDA |
| inflammatory response (GO:0006954) |
CSF1R, CXCL9, CCL11, HP, AIF1, CXCL2, THBS1, CXCL5, FUT7, CCL8, CCL7, CCL5, CCL4, C3AR1, NLRP3, CCL2, CCR5, CCL25, SLC11A1, TLR1, CXCL10, CXCL11, KRT16, CHI3L1, SIGLEC1, FCGR2B, NAIP |
| innate immune response (GO:0045087) |
IFITM3, SHMT2, SLA, ADAR, TREM2, IFIT1, IFIH1, CLEC7A, UBD, DHX58, RPL39, DDX58, SLC11A1, MX1, RNASE6, ISG15, BST2, CXCL10, IFI27, SLPI, KRT16, CLEC6A, SAA1, IRF7, CD300E, CLEC4E, CFB |