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. 2022 Nov 29;13:1050224. doi: 10.3389/fphar.2022.1050224

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Copyright © 2022 Jin, Luo, Li, Zhao, Ouyang, Yao, Chen, Ling, Zhu, Chen, Liao, Pi and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Characterization of Cur and RV-coloaded PLGA nanoparticles. (A) Scheme illustrates the preparation of Cur-RV NPs and PM@Cur-RV NPs using emulsification method. (B) Size distribution of Cur-RV NPs and PM@Cur-RV NPs, respectively. (C) Representative morphology photos of Cur-RV NPs and PM@Cur-RV NPs imaged by scanning electron microscope (1bar = 2 μm). (D) UV-vis spectrum of free Cur, RV and Cur-RV NPs indicated that Cur and RV were both successfully encapsulated in Cur-RV NPs, which shown by the similar absorption peaks at around 210 nm. (E) SDS-PAGE protein analysis of platelet membrane (PM), and PM@Cur-RV NPs (the samples were determined at same protein concentrations).