TABLE 4.
Significantly differential metabolites of RCC vs. BKT groups and RCC vs. HC groups.
| Group | FC | VIP | P | Trend | Pathway |
|---|---|---|---|---|---|
| RCC vs. BKT | |||||
| 3-β-D-Galactosyl-sn-glycerol | 0.296 | 3.723 | <0.001 | ↓ | Galactose metabolism |
| γ-Aminobutyryl-lysine | 0.425 | 4.769 | <0.001 | ↓ | Amino acid metabolism |
| 7,8-Dihydroneopterin | 0.419 | 3.349 | <0.001 | ↓ | Folate biosynthesis |
| LPC 19:2 | 0.589 | 4.611 | <0.001 | ↓ | Glycerophospholipid metabolism |
| RCC vs. HC | |||||
| 3-β-D-Galactosyl-sn-glycerol | 0.322 | 3.853 | <0.001 | ↓ | Galactose metabolism |
| γ-Aminobutyryl-lysine | 0.485 | 3.687 | <0.001 | ↓ | Amino acid metabolism |
| 7,8-Dihydroneopterin | 0.500 | 3.167 | <0.001 | ↓ | Folate biosynthesis |
| LPC 19:2 | 0.441 | 3.239 | <0.001 | ↓ | Glycerophospholipid metabolism |
| 6-Keto-prostaglandin F1α | 2.800 | 3.042 | <0.001 | ↑ | Arachidonic Acid Metabolism |
| 17α,21-Dihydroxypregnenolone | 2.119 | 2.722 | <0.001 | ↑ | Steroid hormone biosynthesis |
| γ-Glutamylphenylalanine | 1.932 | 1.659 | 0.006 | ↑ | Amino acid metabolism |
Note: HC, healthy control; BKT, benign kidney tumor; RCC, renal cell carcinoma; LPC, lysophosphatidylcholine; FC, fold change; VIP, variable importance for the projection.