TABLE 3.
Sexual hormones level of the patients before and after 8 weeks intervention.
Variable | Group A: Flour capsule -placebo (n = 22) | Group B: Ginger (n = 21) | Group C: Cinnamon (n = 20) | Group D: Metformin (n = 20) | P-value** | |
FSH (mIu/ml) | Before | 8.15 ± 8.57 | 5.53 ± 1.56 | 8.3 ± 3.73 | 8.61 ± 8.54 | 0.02 |
After | 10.02 ± 13.09 | 4.29 ± 1.56 a | 8.09 ± 6.93 | 12.46 ± 21.03 c | ||
p-value* | 0.19 | 0.006 | 0.37 | 0.10 | ||
LH (mIu/ml) | Before | 13.91 ± 15.5 | 19.47 ± 20.44 | 12.72 ± 6.56 | 11.02 ± 6.03 | 0.02 |
After | 9.1 ± 9.36 | 6.66 ± 2.5 | 10.88 ± 4.87 b | 14.67 ± 16.12 b,c | ||
p-value* | 0.17 | 0.001 | 0.26 | 0.82 | ||
Testosterone (ng/dl) | Before | 65.07 ± 26.61 | 61.15 ± 20.46 | 65.8 ± 29.63 | 62.6 ± 32 | 0.01 |
After | 61.05 ± 24.36 | 62.1 ± 26.03 c,d | 50.05 ± 24.86 a | 49.5 ± 27.54 | ||
p-value* | 0.39 | 0.82 | < 0.001 | 0.001 | ||
DHEA (ng/ml) | Before | 1845.6 ± 1197.92 | 1682.6 ± 897.11 | 2079 ± 1209.21 | 2842.8 ± 2846.67 | 0.37 |
After | 1890.6 ± 1332.34 | 1719.7 ± 814.62 | 1862.5 ± 1020.94 | 2491.4 ± 1922.58 | ||
p-value* | 0.85 | 0.65 | 0.11 | 0.20 | ||
SHBG (nmol/L) | Before | 51.9 ± 26.02 | 63.27 ± 29.85 | 45.85 ± 27.47 | 41 ± 15.54 | 0.16 |
After | 47.9 ± 22.49 | 55.55 ± 21.01 | 52.22 ± 33.69 | 46.36 ± 28.41 | ||
p-value* | 0.55 | 0.03 | 0.16 | 0.97 | ||
FAI | Before | 1.68 ± 1.41 | 1.24 ± 0.87 | 2.28 ± 2.15 | 1.92 ± 1.42 | 0.22 |
After | 1.71 ± 1.45 | 1.26 ± 0.96 | 1.88 ± 2.3 | 1.42 ± 1.14 | ||
p-value* | 0.79 | 0.47 | 0.03 | 0.31 |
Values for continuous variables, as mean ± standard deviation.
*Within group comparison.
**Before-Baseline parameters are compared using one-way ANOVA. P < 0.05 is considered significant (P-value numbers marked in bold indicate numbers that are significant).
aSignificant difference compare to group A (p < 0.05).
bSignificant difference compare to group B (p < 0.05).
cSignificant difference compare to group C (p < 0.05).
dSignificant difference compare to group D (p < 0.05).
FSH, Follicle-Stimulating Hormone; LH, Luteinizing Hormone; DHEA, Dehydroepiandrosterone; SHBG, Sex Hormone Binding Globulin; FAI, Free Androgen Index.