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. 2022 Nov 29;13:1007461. doi: 10.3389/fimmu.2022.1007461

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Copyright © 2022 Xiao, Wang, Wang, Dai, Liang, Ye, Luo, Zhang, Liu, Cheng and Peng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Distinct genomic profiles of the two clusters. The co-occurrence or mutual exclusivity of the top 25 most mutated genes in (A) cluster1 and (B) cluster2. *p < 0.01, `p < 0.05. (C) Demonstration of the 11 most altered genes between the clusters by the forest plot. Frequency comparison according to (D) variant type, (E) SNV, and (F) variant classification between the two clusters. (G) Amplifications and deletions in two clusters of SOX family by GISTIC 2.0. ***p < 0.001, **p < 0.01, *p < 0.05, NS, no significance.