Table 1.

Linear regression analysis of INSL3 vs baseline and stimulated LH, FSH, testosterone in the delayed puberty and adult cohorts.

	Boys with CHH			Boys with CDGP				Men with CHH			Eugonadal men
INSL3 versus							INSL3 versus
	r	r 2	P-value	r	r 2	P-value		r	r 2	P-value	r	r 2	P-value
Baseline LH (IU/L)	0.24	0.11	0.39	1.205	0.07	0.05	Baseline LH (IU/L)	1.78	0.17	0.07	0.56	0.04	0.38
4hr LH (IU/L) (GnRHa)	-2.76	0.005	0.85	23.48	0.17	0.003	30min LH (IU/L) (GnRH)	12.69	0.03	0.48	4.54	0.03	0.47
24hr LH (IU/L) (GnRHa)	-0.75	0.005	0.86	9.75	0.26	0.0001	4hr LH (IU/L) (GnRH)	6.90	0.07	0.25	1.16	0.03	0.45
Baseline FSH (IU/L)	2.74	0.23	0.19	1.26	0.06	0.09	Baseline FSH (IU/L)	2.51	0.15	0.10	1.21	0.24	0.02
4hr FSH (IU/L) (GnRHa)	-3.92	0.003	0.88	-5.9	0.04	0.14	30min FSH (IU/L) (GnRH)	3.83	0.03	0.46	2.63	0.16	0.08
24hr FSH (IU/L) (GnRHa)	-10.93	0.21	0.22	-1.26	0.005	0.61	4hr FSH (IU/L) (GnRH)	3.78	0.04	0.40	1.93	0.16	0.08
Baseline T (nmol/L)	0.80	0.03	0.65	4.75	0.30	<0.0001	Baseline T (nmol/L)	16.26	0.09	0.19	3.74	0.04	0.36
4hr T (nmol/L) (GnRHa)	-0.49	0.02	0.72	9.47	0.50	<0.0001	30min T (nmol/L) (GnRH)	17.86	0.12	0.13	4.71	0.08	0.23
24hr T (nmol/L) (GnRHa)	-0.47	0.01	0.79	23.33	0.60	<0.0001	4hr T (nmol/L) (GnRH)	18.03	0.09	0.19	7.16	0.22	0.03

Statistically significant results are highlighted in bold. The regression coefficient r is presented, as well as r² and p-value after linear regression. CHH, congenital hypogonadotrophic hypogonadism; CDGP, constitutional delay of growth and puberty; LH, luteinising hormone; FSH, follicle stimulating hormone; T, testosterone; GnRH, gonadotrophin releasing hormone; GnRHa, gonadotrophin releasing hormone agonist.