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. 2022 Nov 29;13:1019451. doi: 10.3389/fphar.2022.1019451

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Copyright © 2022 Sang, Sun, Ding, Jiang, Han, Gan, Bi and Gong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FYN downregulated the mRNA levels of genes enriched in the Wnt/β-catenin pathway. HCC827OR cells treated with FYN at IC₅₀ for 48 h were harvested for analysis (A) Heatmap of target mRNA expression in control HCC827OR cells and FYN-treated HCC827OR cells. (B) KEGG analysis mostly enriched differentially expressed genes in the Wnt/β-catenin pathway. (C and D) mRNA levels in HCC827OR cells (C) and PC9OR cells (D) were measured by qPCR. FYN, Feiyanning Formula. *p < 0.05, **p < 0.01, ***p < 0.001.