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. 2022 Dec 13;7:161. doi: 10.1038/s41541-022-00590-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — T-cell responses were measured using an interferon gamma (IFNγ) enzyme-linked immune absorbent spot (ELISPOT) assay and represented as spot-forming cells (SFC) per million PBMCs (A and B). Displayed are cumulative ELISPOT results for four peptide pools spanning the SARS-CoV-2 Spike. The data are represented as box and whisker plots where the middle horizontal line marks the median. Each dot represents an individual participant. Within each cohort, antibody data from each timepoint were compared to baseline (i.e., day 1) using Mann–Whitney U test (P-values marked with *0.01 < P < 0.05, **0.001 < P < 0.01, ***0.001 < P < 0.01, ****P < 0.0001).