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. 2022 Dec 13;13:7703. doi: 10.1038/s41467-022-35492-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 10 — When neutrophils migrate from systemic circulation to the pulmonary vasculature in ALI mice, the effect of mechanical deformation and the characteristics of the microenvironment make them more adaptive to defense against pathogens (Prok2^hi Neu). During subsequent trans-endothelial and -epithelial movement, large numbers of neutrophils develop into the Fth1^hi subset, with increased resistance, delayed apoptosis and greater production of inflammatory mediators. Fth1^hi Neu exhibited lower expression of L-selectin (CD62L) and C-X-C motif receptor 2 (Cxcr2), and higher expression of Cxcr4 and intercellular adhesion molecule-1 (Icam1). Some figure elements were created with BioRender.com.