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. 2022 Dec 13;13:7703. doi: 10.1038/s41467-022-35492-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — a–e Representative fluorescence images of anti-Fth1/anti-Ly6G and anti-Prok2/anti-Ly6G-stained airway neutrophils from patients infected with Streptococcus pneumoniae (a), Klebsiella pneumoniae (b) and Haemophilus influenzae (c), as well as patients suffering from pulmonary tumors (d) and ARDS (e). The nuclei were stained with DAPI, displayed in blue. Scale bars, 20 µm. (f) Quantification of the fluorescence intensity in each neutrophil showing the level of Fth1 (n = 81 from 3 patients, 81 from 4 patients, 81 from 3 patients, 81 from 3 patients, 100 from 7 patients, respectively in each group) and Prok2 (n = 84 from 3 patients, 90 from 4 patients, 83 from 3 patients, 83 from 3 patients, 101 from 7 patients, respectively in each group). SP, Streptococcus pneumoniae. KP, Klebsiella pneumoniae. HI, Haemophilus influenzae. TAN, tumor-associated neutrophils. All the samples were biologically independent and three or more independent experiments with similar results were performed. Data are presented as mean ± SEM and analyzed with a 95% confidence interval. Statistical analysis was performed using one-way ANOVA followed by Bonferroni’s post hoc test. Source data are provided as a Source Data file.