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. 2022 Sep 4;13(6):2888–2897. doi: 10.1002/jcsm.13063

Table 1.

Correlation between T2H2O and changes in muscle function, fat fraction, and contractile cross‐sectional area over 3 years

Muscle [left (L)/right (R)] Median T2H2O value (range) ΔNSAD Δ6MWT velocity in m/s Δ6MWT distance in m ΔTUG rate (event/s) Δ10MWT velocity (m/s) N with Dixon data ΔFF (%) ΔcCSA (mm2)
Vastus intermedius (L) 40.0 (34.3–46.4 −8 * −0.18 * −64.8 * −0.04 ** −0.06 * 16 9.4 −54.7
Vastus intermedius (R) 40.6 (35.8–47.2) −11 ** −0.14 −50.4 −0.04 ** −0.06 ** 16 7.8 −181.1
Vastus lateralis (L) 41.4 (27.3–48.0) −9 ** −0.10 −36.0 −0.03 * −0.05 * 16 8.4 −551.0
Vastus lateralis (R) 42.7 (35.2–51.4) −6 −0.08 −28.8 −0.03 * −0.05 * 16 10.3 * −606.1
Vastus medialis (L) 39.5 (26.9–50.1) −8 * −0.20 * −72.0 * −0.02 −0.05 * 16 9.8 ** −315.9
Vastus medialis (R) 42.0 (33.1–48.8) −11 ** −0.24 ** −86.4 ** −0.04 *** −0.07 ** 15 9.7 ** −441.4
Adductor magnus (L) 39.3 (33.1–45.8) −7 * −0.14 −50.4 −0.03 ** −0.04 16 15.5 −40.7
Adductor magnus (R) 39.0 (33.6–47.2 −10 ** −0.18 * −64.8 * −0.04 *** −0.07 ** 16 13.3 −156.9
Gracilis (L) 38.5 (33.4–43.0) −4 −0.15 −54.0 −0.03 ** −0.03 16 9.1 −123.6
Gracilis (R) 37.5 (33.0–44.3) −6 −0.17 * −61.2 * −0.03 ** −0.03 16 3.5 −141.9
Sartorius (L) 38.4 (32.0–43.9) −4 −0.16 * −57.6 * −0.03 ** 0 16 12.0 −142.6
Sartorius (R) 39.3 (34.5–44.8) −8 ** −0.11 −39.6 −0.03 ** −0.03 16 7.9 −88.1
Biceps femoris (L) 39.6 (26.4–51.5) −2 0.05 −18.0 −0.02 0.02 15 5.9 −162.9
Biceps femoris (R) 38.7 (27.7–50.4) −9 ** −0.16 −57.6 −0.03 * −0.02 14 13.6 −181.4
Semimembranosus (L) 38.3 (25.7–47.8) −7 * −0.13 −46.8 −0.03 −0.02 13 13.1 −113.1
Semimembranosus (R) 38.1 (20.3–46.2) −3 −0.08 −28.8 −0.01 0.02 13 10.0 * −168.7
Semitendinosus (L) 36.7 (28.8–44.6) −5 −0.01 −3.6 −0.01 −0.01 16 7.1 −57.8
Semitendinosus (R) 34.8 (22.6–47) −4 −0.09 −32.4 −0.01 0.01 16 9.4 −35.8
Tibialis anterior (L) 39.4 (23.9–49.4) −7 * −0.14 −50.4 −0.02 0 15 4.0 −41.1
Tibialis anterior (R) 38.6 (31.1–53.3) −2 −0.04 −14.4 −0.01 0 15 −2.4 21.0
Extensor digitorum (L) 40.5 (34.2–50) −8 * −0.11 −39.6 −0.03 ** −0.01 15 7.7 * −50.1
Extensor digitorum (R) 39.6 (34.8–48) −2 −0.03 −10.8 −0.02 0.01 15 11.3 −95.3
Peroneus (L) 37.1 (23.9–50) −2 −0.12 −43.2 −0.01 0.01 15 14.5 −159.6
Peroneus (R) 36.4 (25.2–48.2) −3 −0.11 −39.6 0.02 −0.02 14 13.2 −184.5
Tibialis posterior (L) 40.2 (34.1–50.3) −2 −0.11 −39.6 −0.03 * 0.01 15 6.9 −133.8
Tibialis posterior (R) 39.9 (34.8–48.3) −4 −0.06 −21.6 −0.02 −0.02 15 8.4 −129.9
Soleus (L) 37.3 (23.6–50.4) −1 −0.09 −32.4 −0.02 0.01 14 6.1 −14.9
Soleus (R) 38.1 (26.9–49.4) −9 * −0.26 ** −93.6 ** −0.04 ** −0.03 15 10.9 −40.5
Gastrocnemius lateralis (L) 36.9 (25.8–46.2) 5 0.03 10.8 0.01 0.02 14 14.1 −151.1
Gastrocnemius lateralis (R) 37.7 (23.1–47.6) 1 −0.06 −21.6 0 0 13 15.8 −34.0
Gastrocnemius medialis (L) 35.9 (26.2–57) 3 0.07 25.2 0.02 0.05 * 14 3.8 −95.1
Gastrocnemius medialis (R) 38.5 (26.1–60.7) −4 −0.06 −21.6 −0.02 0 14 0.5 −73.8

N, number; Δ6MWT, change in 6‐min walk test between Year 3 and baseline; Δ10MWT, change in 10‐m walk test between Year 3 and baseline; ΔcCSA, change in contractile cross‐sectional area between Year 3 and baseline; ΔFF, change in fat fraction between Year 3 and baseline; ΔNSAD, change in North Star Ambulatory Assessment for Dysferlinopathy between Year 3 and baseline; ΔTUG, change in timed up and go test between Year 3 and baseline.

The table shows mean changes in muscle function tests and their association with high T2H2O. Regression coefficients in bold were statistically significant at the 0.05 level.

*

P < 0.05.

**

P < 0.01.

***

P < 0.001.