. 2022 Sep 4;13(6):2888–2897. doi: 10.1002/jcsm.13063

Table 1.

Correlation between T2_H2O and changes in muscle function, fat fraction, and contractile cross‐sectional area over 3 years

Muscle [left (L)/right (R)]	Median T2_H2O value (range)	ΔNSAD	Δ6MWT velocity in m/s	Δ6MWT distance in m	ΔTUG rate (event/s)	Δ10MWT velocity (m/s)	N with Dixon data	ΔFF (%)	ΔcCSA (mm²)
Vastus intermedius (L)	40.0 (34.3–46.4	−8 ^*	−0.18 ^*	−64.8 ^*	−0.04 ^**	−0.06 ^*	16	9.4	−54.7
Vastus intermedius (R)	40.6 (35.8–47.2)	−11 ^**	−0.14	−50.4	−0.04 ^**	−0.06 ^**	16	7.8	−181.1
Vastus lateralis (L)	41.4 (27.3–48.0)	−9 ^**	−0.10	−36.0	−0.03 ^*	−0.05 ^*	16	8.4	−551.0
Vastus lateralis (R)	42.7 (35.2–51.4)	−6	−0.08	−28.8	−0.03 ^*	−0.05 ^*	16	10.3 ^*	−606.1
Vastus medialis (L)	39.5 (26.9–50.1)	−8 ^*	−0.20 ^*	−72.0 ^*	−0.02	−0.05 ^*	16	9.8 ^**	−315.9
Vastus medialis (R)	42.0 (33.1–48.8)	−11 ^**	−0.24 ^**	−86.4 ^**	−0.04 ^***	−0.07 ^**	15	9.7 ^**	−441.4
Adductor magnus (L)	39.3 (33.1–45.8)	−7 ^*	−0.14	−50.4	−0.03 ^**	−0.04	16	15.5	−40.7
Adductor magnus (R)	39.0 (33.6–47.2	−10 ^**	−0.18 ^*	−64.8 ^*	−0.04 ^***	−0.07 ^**	16	13.3	−156.9
Gracilis (L)	38.5 (33.4–43.0)	−4	−0.15	−54.0	−0.03 ^**	−0.03	16	9.1	−123.6
Gracilis (R)	37.5 (33.0–44.3)	−6	−0.17 ^*	−61.2 ^*	−0.03 ^**	−0.03	16	3.5	−141.9
Sartorius (L)	38.4 (32.0–43.9)	−4	−0.16 ^*	−57.6 ^*	−0.03 ^**	0	16	12.0	−142.6
Sartorius (R)	39.3 (34.5–44.8)	−8 ^**	−0.11	−39.6	−0.03 ^**	−0.03	16	7.9	−88.1
Biceps femoris (L)	39.6 (26.4–51.5)	−2	0.05	−18.0	−0.02	0.02	15	5.9	−162.9
Biceps femoris (R)	38.7 (27.7–50.4)	−9 ^**	−0.16	−57.6	−0.03 ^*	−0.02	14	13.6	−181.4
Semimembranosus (L)	38.3 (25.7–47.8)	−7 ^*	−0.13	−46.8	−0.03	−0.02	13	13.1	−113.1
Semimembranosus (R)	38.1 (20.3–46.2)	−3	−0.08	−28.8	−0.01	0.02	13	10.0 ^*	−168.7
Semitendinosus (L)	36.7 (28.8–44.6)	−5	−0.01	−3.6	−0.01	−0.01	16	7.1	−57.8
Semitendinosus (R)	34.8 (22.6–47)	−4	−0.09	−32.4	−0.01	0.01	16	9.4	−35.8
Tibialis anterior (L)	39.4 (23.9–49.4)	−7 ^*	−0.14	−50.4	−0.02	0	15	4.0	−41.1
Tibialis anterior (R)	38.6 (31.1–53.3)	−2	−0.04	−14.4	−0.01	0	15	−2.4	21.0
Extensor digitorum (L)	40.5 (34.2–50)	−8 ^*	−0.11	−39.6	−0.03 ^**	−0.01	15	7.7 ^*	−50.1
Extensor digitorum (R)	39.6 (34.8–48)	−2	−0.03	−10.8	−0.02	0.01	15	11.3	−95.3
Peroneus (L)	37.1 (23.9–50)	−2	−0.12	−43.2	−0.01	0.01	15	14.5	−159.6
Peroneus (R)	36.4 (25.2–48.2)	−3	−0.11	−39.6	0.02	−0.02	14	13.2	−184.5
Tibialis posterior (L)	40.2 (34.1–50.3)	−2	−0.11	−39.6	−0.03 ^*	0.01	15	6.9	−133.8
Tibialis posterior (R)	39.9 (34.8–48.3)	−4	−0.06	−21.6	−0.02	−0.02	15	8.4	−129.9
Soleus (L)	37.3 (23.6–50.4)	−1	−0.09	−32.4	−0.02	0.01	14	6.1	−14.9
Soleus (R)	38.1 (26.9–49.4)	−9 ^*	−0.26 ^**	−93.6 ^**	−0.04 ^**	−0.03	15	10.9	−40.5
Gastrocnemius lateralis (L)	36.9 (25.8–46.2)	5	0.03	10.8	0.01	0.02	14	14.1	−151.1
Gastrocnemius lateralis (R)	37.7 (23.1–47.6)	1	−0.06	−21.6	0	0	13	15.8	−34.0
Gastrocnemius medialis (L)	35.9 (26.2–57)	3	0.07	25.2	0.02	0.05 ^*	14	3.8	−95.1
Gastrocnemius medialis (R)	38.5 (26.1–60.7)	−4	−0.06	−21.6	−0.02	0	14	0.5	−73.8

N, number; Δ6MWT, change in 6‐min walk test between Year 3 and baseline; Δ10MWT, change in 10‐m walk test between Year 3 and baseline; ΔcCSA, change in contractile cross‐sectional area between Year 3 and baseline; ΔFF, change in fat fraction between Year 3 and baseline; ΔNSAD, change in North Star Ambulatory Assessment for Dysferlinopathy between Year 3 and baseline; ΔTUG, change in timed up and go test between Year 3 and baseline.

The table shows mean changes in muscle function tests and their association with high T2_H2O. Regression coefficients in bold were statistically significant at the 0.05 level.

P < 0.05.

^**

P < 0.01.

^***

P < 0.001.