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. 2022 Sep 26;13(6):2985–2998. doi: 10.1002/jcsm.13091

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© 2022 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Cell–cell interactions inferred from scRNA‐seq data. (A) Cell–cell interaction network among the major cell types in each experiment group. Edge width represents number of interactions between the two connecting cell types. P6DX group has a less dense network comparing to control and P6Sham groups. (B) Bar plot to compare number of interactions and interaction strength among the three groups. P6DX has fewest interactions and lowest interaction strength. (C) Heatmap to compare differential number of interactions and interaction strength between P6DX and control group. P6DX has fewer interactions and lower interaction strength in most cell type pairs. (D) Bar plot to compare the overall information flow of each signalling pathway. The signalling pathways coloured red are enriched in control, and these coloured blue are enriched in the P6DX. (E) Expression of signalling genes related to TENASCIN signalling pathway in control and P6DX groups.