TABLE 1.
Participants' characteristics for all MarkVCID participants and each sub‐cohort
| Cohort | N | Age | Sex (F) | Education | Hypertension (Y) | Diabetes (Y) | Smoking Status (Y) | mFW | EFC | WMH | TCV |
|---|---|---|---|---|---|---|---|---|---|---|---|
| All | 523 | 71.6 ± 8.1 [32.2; 90] | 321; 61.4 |
15.4 ± 3.1 [4; 24] |
265; 50.7 | 103; 19.7 | 195; 37.3 | 0.23 ± 0.05 [0.13; 0.47] |
−0.51 ± 0.89 [−2.9; 1.75] |
7.45 ± 11.32 [0; 87.17] |
1349.0 ± 152.8 [997.2; 1876.6] |
| JHU | 86 | 69.3 ± 6.9 [53.2; 88.9] | 55; 64 |
16.2 ± 2.5 [12; 24] |
43; 50 | 21; 24.4 | 35; 40.7 | 0.23 ± 0.04 [0.16; 0.32] |
−0.18 ± 0.79 [−2.2; 1.63] |
9.68 ± 13.55 [0.07; 70.91] |
1312.5 ± 129.5 [1022.6; 1642.8] |
| UCSF | 54 | 77.4 ± 7.4 [55.1; 90] | 28; 51.9 | 17.0 ± 2.1 [12; 20] | 26; 48.1 | 6; 11.1 | 21; 38.9 | 0.25 ± 0.04 [0.17; 0.37] |
−0.19 ± 0.86 [−2.52; 1.23] |
9.16 ± 12.16 [0.13; 59.57] |
1407.9 ± 168.8 [1134.1; 1785.7] |
| UKY | 125 | 74.2 ± 7.7 [55.8; 90] | 75; 60 | 16.1 ± 2.6 [12; 22] | 71; 56.8 | 22; 17.6 | 47; 37.6 | 0.24 ± 0.04 [0.17; 0.35] |
−0.41 ± 0.86 [−2.9; 1.38] |
7.06 ± 8.69 [0; 57.98] |
1386.6 ± 140.4 [1068.4; 1794.4] |
| UNM | 79 | 70.8 ± 8.8 [47.5; 90] | 38; 48.1 | 16.4 ± 2.7 [10; 20] | 31; 39.2 | 4; 5.1 | 35; 44.3 | 0.26 ± 0.06 [0.18; 0.47] |
−0.54 ± 1.01 [−2.86; 1.75] |
13.26 ± 17.4 [0; 87.17] |
1416.2 ± 155.4 [1028.3; 1876.6] |
| USC | 58 | 68.7 ± 9.0 [32.2; 90] | 38; 65.5 |
11.0 ± 3.3 [4; 17] |
35; 60.3 | 22; 37.9 | 24; 41.4 | 0.21 ± 0.03 [0.16; 0.37] |
−1.09 ± 0.78 [−2.35; 0.72] |
4.23 ± 5.08 [0.19; 24.45] |
1267.7 ± 142.7 [997.2; 1629.8] |
| UTHSCSA | 121 | 69.9 ± 6.9 [55.9; 89.3] | 87; 71.9 |
14.5 ± 2.7 [6; 20] |
59; 48.8 | 28; 23.1 | 33; 27.3 | 0.19 ± 0.03 [0.13; 0.27] |
−0.68 ± 0.76 [−2.36; 1.34] |
3.26 ± 5.04 [0.18; 42.91] |
1304.4 ± 138.4 [1045.1; 1634.9] |
Note: Continuous variable: mean ± SD [min; max]; categorical variable: N; %. Cohort 1 includes UKY and UCSF, Cohort 2 UNM and JHU, and Cohort 3 UTHSCSA and USC.
Abbreviations: EFC, executive function composite score; mFW, mean free water; TCV, total cranial volume (cc); WMH, white matter hyperintensity (cc). JHU, Johns Hopkins University School of Medicine; RUSH, Rush University Medical Center/Illinois Institute of Technoly; UCSF, Universities of California San Francisco, Davis, and Los Angeles; UKY, University of Kentucky; UNM, University of New Mexico Health Sciences Center; USC, University of Southern California; UTHSCSA. University of Texas Health Science Center at San Antonio.