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. Author manuscript; available in PMC: 2022 Dec 13.
Published in final edited form as: Hear Res. 2022 May 7;426:108513. doi: 10.1016/j.heares.2022.108513

Fig. 4.

Fig. 4.

Cisplatin activates caspase-3-mediated hair cell death. Maximum-intensity projections of confocal images showing HCS-1 staining of hair cell membranes and cleaved caspase-3 staining within the neuromast of 6 dpf larvae treated with 0.1% DMSO (A), 250 μM cisplatin (B), and 1 mM cisplatin (C) for 2 h, followed by recovery for 2 h. Median percentages of neuromasts with activated caspase-3 staining are greater in cisplatin-treated zebrafish compared to DMSO-treated zebrafish in a dose-dependent manner (D, **p = 0.003, ****p < 0.0001, Dunn’s multiple comparisons test). n = 90 neuromasts. N = 3 experimental trials. Error bars = 95% CI.