Table 5.

Terms, definitions, and features of chronicity in ileum

Architectural changes

Villi: Variability in size and shape, Shortening, broadening of villous tips, Irregularity, Loss Crypt distortion: Branching, Shortening, atrophy, loss, Irregular distance between the crypts

Epithelial cell change

Metaplasia: Pyloric, gastric surface metaplasia

Goblet cell rich crypts (hypercrinia or goblet cell hyperplasia)

An increase beyond 50% of the normal range (up to 50 goblet cells per 100 epithelial cells), occurs in Crohn’s disease but can also occur in other conditions

Paneth cells loss or hyperplasia

Inflammatory cells composition and distribution

Basal plasmacytosis Mucosal (basal) and submucosal lymphoid aggregates

Granulomas

Fibrosis