Table 1. Proportion of amniocentesis indicators and abnormal detection rates in each group by karyotyping and CNV-seq.
| Indicators for prenatal diagnosis | Constituent rate (No. of cases/total cases) | Abnormal detection rate |
|---|---|---|
| AMA | 27.86% (229/822) | 11.79% (27/229) |
| Maternal serum screening high-risk | 17.64% (145/822) | 15.17% (22/145) |
| Abnormal fetal ultrasonography | 39.29% (323/822) | 13.93% (45/323) |
| History of adverse reproductive outcomes | 16.42% (135/822) | 8.89% (12/135) |
| NIPT high-risk | 7.06% (58/822) | 37.93% (22/58)* |
| Mixed indicators | 8.76% (72/822) | 20.83% (15/72)** |
| Single indicator | 83.45% (686/822) | 13.85% (95/686) |
| ≥2 indicators | 16.55% (136/822) | 17.65% (24/136) |
| Total | 100% (822/822) | 14.48% (119/822) |
Notes.
- AMA
- advanced maternal age
- NIPT
- non-invasive prenatal testing
*
NIPT vs AMA, P < 0.0001; NIPT vs maternal serum screening high-risk, P = 0.0004; NIPT vs abnormal fetal ultrasonography, P < 0.0001; NIPT vs history of adverse reproductive outcomes, P < 0.0001; NIPT vs mixed indicators, P = 0.0317.
**
Mixed indicators vs history of adverse reproductive outcomes, P = 0.0151.