. 2022 Nov 29;8(12):2552–2563. doi: 10.1021/acsinfecdis.2c00445

Table 1. Activity of MGB-BP-3 against ESKAPE Pathogens and Potentiation Results with PAβN against Gram-Negative Pathogens Using Checkerboard Assays^a.

	S. aureus ATCC 43300	E. faecalis ATCC 51299	E. coli ATCC 25922	P. aeruginosa ATCC 27893	A. baumannii ATCC 19606	K. pneumoniae ATCC 700603
MIC₈₀ (μM) MGB-BP-3	0.2	0.2	>100	>100	>100	>100
MIC₈₀ (μM) MGB-BP-3 with 100 μg/mL PAβN	NT	NT	0.05	0.2	0.1	0.78
FICI MGB-BP-3 and PAβN	NT	NT	≤0.03	≤0.1	≤0.1	≤0.2

Fractional inhibitory concentration indices (FICIs) from checkerboard assays indicate significant synergy for values <0.5.

Table 1. Activity of MGB-BP-3 against ESKAPE Pathogens and Potentiation Results with PAβN against Gram-Negative Pathogens Using Checkerboard Assaysa.